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D-vitamin-toksicitet er ikke et problem

Selv ved meget højt indtag ser D-vitamin ikke ud til at forårsage toksicitet, afslører en amerikansk undersøgelse.

D-vitamin-toksicitet er ikke et problemNogle eksperter har advaret folk mod at tage D-vitamin i doser, der overstiger den anbefalede daglige tilførsel (ADT), idet de har hævdet, at overskydende D-vitamin kan føre til problemer såsom hypercalcæmi, en tilstand karakteriseret ved forhøjed calciumindhold i blodet, der kan forårsage svaghed, nyresten og hjerne- og hjerteforstyrrelser. Imidlertid har en undersøgelse foretaget af forskere ved Mayo Clinic vist, at D-vitamin-toksicitet ikke er et problem. Forskerholdet analyserede bloddata indsamlet i perioden 2002-2011 fra patienter, der deltog i Rochester Epidemiologi Project, og gjorde nogle interessante observationer i den forbindelse.

  • På baggrund af 20.308 målinger viste det sig, at otte procent af deltagerne havde D-vitamin-niveauer over 50 ng/mL, og mindre end én procent havde niveauer over 100 ng/mL
  • Selv blandt dem med høje niveauer af D-vitamin (over 50 ng / ml) var der ikke en øget risiko for hypercalcæmi eller forhøjet serumcalcium
  • Kvinder over 65 var mest tilbøjelige til at have D-vitamin-niveauer over 50 ng / mL, da det ofte er dem, der tager kosttilskud
  • Forekomsten af D-vitamin-niveauer højere end 50 ng / mL steg i løbet af den 10-årige studieperiode. Til at begynde med omfattede denne gruppe ni ud af 100.000 deltagere. Ved slutningen af undersøgelsen var det tilsvarende tal 233 ud af 100.000.

Det er almindeligt kendt, at anvendelsen af D-vitamin i de vestlige lande er steget i de seneste ti år. Folk tager D-vitamin for at styrke knogler og immunforsvaret men også for at sænke deres risiko for diabetes, cancer, hjerte-kar-sygdomme og andre sygdomme, hvor D-vitamin i denne forbindelse har vist sig at spille en vigtig rolle. Forskerne fra The Mayo Clinic ønskede at undersøge, om tilskud i høje doser havde konsekvenser for menneskers sundhed men fandt, at giftige niveauer faktisk er meget sjældent.

 

Kilde

Vitamin D toxicity rare in people who take supplements (report)

www.sciencedaily.com, 30 April 2015


 

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    1 x afterRenderModule mod_custom (Supplerer du med kosttilskud) (1.28KB) (0%)
    17μs
    1 x afterRenderModule mod_custom (Kært barn har mange navne) (1.28KB) (0%)
    17μs
    1 x afterRenderModule mod_custom (Vil du vide mere om D-vitamin) (1.28KB) (0%)
    17μs
    1 x afterRenderModule mod_custom (Læs også .....) (1.27KB) (0%)
    17μs
    1 x afterRenderModule mod_custom (Kolesterolsænkning uden bivirkninger:) (1.28KB) (0%)
    17μs
    1 x afterRenderRawModule mod_custom (Nyttige Links) (912B) (0%)
    16μs
    1 x Before Access::preloadPermissions (com_content) (1.6KB) (0%)
    16μs
    1 x afterRenderRawModule mod_custom (Læs også .....) (1.02KB) (0%)
    16μs
    1 x afterRenderModule mod_custom (Læs også Helsedebatten) (1.27KB) (0%)
    16μs
    1 x afterRenderModule mod_menu (Ved du....) (1.25KB) (0%)
    16μs
    1 x beforeRenderRawModule mod_languages (Sprogskift Mobil) (912B) (0%)
    16μs
    1 x beforeRenderRawModule mod_menu (Ved du....) (720B) (0%)
    13μs
    1 x beforeRenderModule mod_tags_popular (Søg) (5.66KB) (0%)
    12μs
    3 x beforeRenderModule mod_custom () (704B) (0%)
    12μs
    1 x beforeRenderRawModule mod_custom (Styrk immunforsvaret) (720B) (0%)
    11μs
    1 x beforeRenderRawModule mod_menu (Får du nok vitaminer og mineraler?) (2.48KB) (0%)
    11μs
    1 x beforeRenderRawModule mod_custom (Q10-kapsler fik Alan ud af sengen:) (1.05KB) (0%)
    11μs
    1 x beforeRenderRawModule mod_custom (Få yderligere og mere detaljeret viden ) (752B) (0%)
    10μs
    1 x beforeRenderRawModule mod_custom (Anti-aging) (720B) (0%)
    10μs
    1 x beforeRenderRawModule mod_menu (Anti-aging) (2.47KB) (0%)
    10μs
    1 x beforeRenderModule mod_menu (Får du nok vitaminer og mineraler?) (2.11KB) (0%)
    10μs
    1 x beforeRenderModule mod_custom (Vitamin- og mineral guiden ) (1.31KB) (0%)
    9μs
    1 x beforeRenderModule mod_custom (Styrk immunforsvaret) (336B) (0%)
    9μs
    1 x beforeRenderModule mod_menu (Ved du....) (336B) (0%)
    9μs
    1 x beforeRenderRawModule mod_finder () (2.3KB) (0%)
    9μs
    1 x beforeRenderModule mod_menu (Anti-aging) (2.09KB) (0%)
    9μs
    1 x beforeRenderModule mod_menu (Slankekur med) (336B) (0%)
    9μs
    1 x beforeRenderModule mod_menu (Vejen til bedre velvære) (336B) (0%)
    9μs
    2 x beforeRenderModule mod_finder () (704B) (0%)
    9μs
    1 x beforeRenderRawModule mod_custom (Supplerer du med kosttilskud) (736B) (0%)
    8μs
    1 x beforeRenderRawModule mod_custom (Vælg dit kosttilskud med omhu) (736B) (0%)
    8μs
    1 x beforeRenderRawModule mod_custom (Kolesterolsænkning uden bivirkninger:) (752B) (0%)
    8μs
    1 x beforeRenderModule mod_custom (Få yderligere og mere detaljeret viden ) (368B) (0%)
    8μs
    1 x beforeRenderModule mod_custom (Læs også artiklen) (1.44KB) (0%)
    8μs
    1 x beforeRenderModule mod_custom (Anti-aging) (336B) (0%)
    8μs
    1 x beforeRenderModule mod_custom (Supplerer du med kosttilskud) (352B) (0%)
    8μs
    1 x beforeRenderModule mod_custom (Kært barn har mange navne) (352B) (0%)
    8μs
    1 x beforeRenderModule mod_custom (Vil du vide mere om D-vitamin) (352B) (0%)
    8μs
    1 x beforeRenderModule mod_custom (Læs også .....) (336B) (0%)
    8μs
    1 x beforeRenderRawModule mod_custom (Fokus på D-vitamin) (720B) (0%)
    8μs
    1 x beforeRenderRawModule mod_custom (Læs også Helsedebatten) (736B) (0%)
    8μs
    1 x beforeRenderRawModule mod_custom (Nyttige Links) (720B) (0%)
    8μs
    1 x beforeRenderModule mod_custom (Vælg dit kosttilskud med omhu) (352B) (0%)
    8μs
    1 x beforeRenderModule mod_custom (Læs også Helsedebatten) (352B) (0%)
    8μs
    1 x beforeRenderModule mod_custom (Q10-kapsler fik Alan ud af sengen:) (1.42KB) (0%)
    8μs
    1 x beforeRenderModule mod_custom (Kolesterolsænkning uden bivirkninger:) (352B) (0%)
    8μs
    1 x beforeRenderRawModule mod_custom (Kært barn har mange navne) (736B) (0%)
    7μs
    1 x beforeRenderRawModule mod_custom (Læs også .....) (720B) (0%)
    7μs
    1 x beforeRenderModule mod_custom (Fokus på D-vitamin) (336B) (0%)
    7μs
    1 x beforeRenderRawModule mod_custom (Vil du vide mere om D-vitamin) (736B) (0%)
    7μs
    1 x beforeRenderModule mod_custom (Nyttige Links) (336B) (0%)
    7μs
    1 x beforeRenderModule mod_custom (Søg mere info...) (720B) (0%)
    6μs
    1 x beforeRenderModule mod_languages (Sprogskift) (720B) (0%)
    5μs
    1 x beforeRenderModule mod_languages (Sprogskift Mobil) (720B) (0%)
    3μs
43 statements were executed, 7 of which were duplicates, 36 unique489ms1.34MB
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  • SELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid` FROM `has_content` AS `c` INNER JOIN `has_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `has_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `has_content` AS `c2` ON `a2`.`id` = `c2`.`id` INNER JOIN `has_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2 WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'da-DK' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-05-17 20:12:29') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-05-17 20:12:29') AND c2.state = 13.73ms1.5KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`,( SELECT COUNT(`i`.`id`) FROM `has_content` AS `i` WHERE `i`.`catid` = `c`.`id` AND `i`.`state` = 1 AND `i`.`language` IN (:preparedArray5,:preparedArray6)) AS `numitems` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`34.83ms4.05KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END AS `publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`metadata`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`featured`,`a`.`language`,LENGTH(`a`.`fulltext`) AS `readmore`,`a`.`ordering`,`fp`.`featured_up`,`fp`.`featured_down`,CASE WHEN `c`.`published` = 2 AND `a`.`state` > 0 THEN 2 WHEN `c`.`published` != 1 THEN 0 ELSE `a`.`state` END AS `state`,`c`.`title` AS `category_title`,`c`.`path` AS `category_route`,`c`.`access` AS `category_access`,`c`.`alias` AS `category_alias`,`c`.`language` AS `category_language`,`c`.`published`,`c`.`published` AS `parents_published`,`c`.`lft`,CASE WHEN `a`.`created_by_alias` > ' ' THEN `a`.`created_by_alias` ELSE `ua`.`name` END AS `author`,`ua`.`email` AS `author_email`,`uam`.`name` AS `modified_by_name`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,COALESCE(NULLIF(ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1), 0), 0) AS `rating`,COALESCE(NULLIF(`v`.`rating_count`, 0), 0) AS `rating_count` FROM `has_content` AS `a` LEFT JOIN `has_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `has_users` AS `ua` ON `ua`.`id` = `a`.`created_by` LEFT JOIN `has_users` AS `uam` ON `uam`.`id` = `a`.`modified_by` LEFT JOIN `has_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `has_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `has_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND `a`.`catid` IN (:preparedArray5) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`language` IN (:preparedArray6,:preparedArray7) ORDER BY RAND() ASC LIMIT 15112ms243.28KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT MAX(`tag_id`) AS `tag_id`,COUNT(*) AS `count`,MAX(`t`.`title`) AS `title`,MAX(`t`.`access`) AS `access`,MAX(`t`.`alias`) AS `alias`,MAX(`t`.`params`) AS `params`,MAX(`t`.`language`) AS `language` FROM `has_contentitem_tag_map` AS `m` INNER JOIN `has_ucm_content` AS `ucm` ON `m`.`content_item_id` = `ucm`.`core_content_item_id` AND `m`.`type_id` = `ucm`.`core_type_id` INNER JOIN `has_categories` AS `cat` ON `ucm`.`core_catid` = `cat`.`id` INNER JOIN `has_tags` AS `t` ON `tag_id` = `t`.`id` INNER JOIN `has_ucm_content` AS `c` ON `m`.`core_content_id` = `c`.`core_content_id` WHERE `t`.`access` IN (:preparedArray1,:preparedArray2) AND `t`.`published` = 1 AND `cat`.`published` > 0 AND `t`.`language` IN (:preparedArray3,:preparedArray4) AND `m`.`type_alias` = `c`.`core_type_alias` AND `c`.`core_state` = 1 AND (`c`.`core_access` IN (:preparedArray5,:preparedArray6) OR `c`.`core_access` = 0) AND (`c`.`core_publish_up` IS NULL OR `c`.`core_publish_up` = :nullDate2 OR `c`.`core_publish_up` <= :nowDate2) AND (`c`.`core_publish_down` IS NULL OR `c`.`core_publish_down` = :nullDate3 OR `c`.`core_publish_down` >= :nowDate3) GROUP BY `tag_id`,`t`.`title`,`t`.`access`,`t`.`alias` ORDER BY RAND() LIMIT 15241ms5.25KBParams/modules/mod_tags_popular/src/Helper/TagsPopularHelper.php:183Copy
  • SELECT `c2`.`language`,`c2`.`id` FROM `has_menu` AS `c` INNER JOIN `has_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `has_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `has_menu` AS `c2` ON `a2`.`id` = `c2`.`id` WHERE `c`.`id` = :id1.19ms1.47KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT `name`,`element` FROM `has_extensions` WHERE `type` = 'plugin' AND `folder` = 'finder' AND `enabled` = 13.81ms640B/administrator/components/com_finder/src/Helper/LanguageHelper.php:135Copy
  • SELECT `title` FROM `has_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1,5)2.1ms584B/administrator/components/com_finder/src/Indexer/Taxonomy.php:314Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM has_fields AS a LEFT JOIN `has_languages` AS l ON l.lang_code = a.language LEFT JOIN has_users AS uc ON uc.id=a.checked_out LEFT JOIN has_viewlevels AS ag ON ag.id = a.access LEFT JOIN has_users AS ua ON ua.id = a.created_user_id LEFT JOIN has_fields_groups AS g ON g.id = a.group_id WHERE ( (`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform AND `a`.`language` IN (:preparedArray5,:preparedArray6) ORDER BY a.ordering ASC1.98ms4.75KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `title` FROM `has_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1,5)3.46ms584B/administrator/components/com_finder/src/Indexer/Taxonomy.php:314Copy
  • SELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count FROM `has_scheduler_tasks` AS `a` WHERE `a`.`state` = 15.63ms1.37KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:466Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`3.98ms3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`2.2ms3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `session_id` FROM `has_session` WHERE `session_id` = ?1.93ms1KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291Copy
  • UPDATE `has_session` SET `data` = ? , `time` = ? WHERE `session_id` = ?2.41ms592BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy