Skip to main content

Brystkræft: Mere selen i blodet forbedrer overlevelsen

Brystkræft: Mere selen i blodet forbedrer overlevelsenBrystkræft er den hyppigste kræftform blandt kvinder, og selvom behandlingerne er blevet bedre, er der stadig mange, der dør af sygdommen. Et svensk-tysk studie har nu afsløret, at et lavt selenindhold i blodet giver en dårligere prognose. Samtidig kan et højere selenindhold i blodet øge chancen for at overleve brystkræft. Det er derfor problematisk at selenmangel er så udbredt i Europa. Ifølge forskerne bag det nye studie kan en måling af selenindholdet i blodet derfor bruges til at optimere blodets indhold og derigennem forbedre behandlingen.

Stadig flere får brystkræft, og i 2020 var der på verdensplan 685.000, der døde af sygdommen på trods af bedre behandlinger. Det sker også, at mange færdigbehandlede, som er erklæret raske, senere får tilbagefald. Derfor er der stadig brug for nye terapier, som virker på sigt.
Normalt ser lægerne på typen og størrelsen af kræftknuder samt angrebne lymfeknuder for at stille en prognose. Men nu ser det ud til, at en måling af patientens selenstatus i blodet kan give et endnu bedre billede.
Selen indgår i omkring 25 selenholdige proteiner og enzymer, som har betydning for skjoldbruskkirtlens hormoner, cellernes energiomsætning og regulering af cellevækst. Selen indgår desuden i nogle særdeles kraftige antioxidanter (GPX 1-6). På den måde bidrager de selenholdige proteiner til cellernes metaboliske processer, og at cellerne samtidig er beskyttet mod skader, uhensigtsmæssig celledeling og kræft.
Da de selenholdige proteiner indgår i et kompliceret stofskifte, er det mest almindeligt at man måler mængden af selenoprotein P i blodet som markør for kroppens selenstatus.

Jo mere selen, jo bedre beskyttelse mod kræft

Forskere fra Lunds Universitet i Sverige udførte det nye studie i samarbejde med forskere fra forskellige universiteter i Tyskland. Forskerne analyserede blodprøver fra 1996 patienter (heraf otte mænd), som netop var diagnosticeret med primær invasiv brystkræft. Forskerne så nærmere på blodets indhold af selenoprotein P, GPX-3 og total-selen. Det var altså ret nyt, at man så nærmere på hele tre markører for selen.
Studiet afslørede, at den femtedel, som havde mest selen i blodet i form af de tre markører, havde 50 procent større chance for at overleve sygdommen efter otte år i forhold til den femtedel, som havde mindst selen i blodet i forhold til de tre markører.
Det viste sig med andre ord, at patienter med høje selenniveauer i blodet havde den bedste kræftbeskyttelse og den laveste risiko for at dø af sygdommen.
Ifølge forskerne bag det nye studie kan en måling af selenindholdet i blodet derfor bruges til at optimere blodets indhold og derigennem forbedre behandlingen på sigt.

Den selenholdige antioxidant GPX beskytter mod oxidativ stress og tilbagefald

Ved oxidativ stress er der er en ubalance mellem frie radikaler og antioxidanter. Frie radikaler er livsvigtige, da de indgår i en række metaboliske processer. Men da det er nogle meget reaktive molekyler, kan de også blive sundhedsfarlige, hvis de angriber celler og væv. Påvirkningen af frie radikaler øges gevaldigt af stress, overvægt, tobaksrøg, aldringsprocesser og forgiftninger. Vores eneste værn mod de frie radikaler og oxidativ stress er forskellige antioxidanter, hvor GPX spiller en ganske særlig rolle i cellernes første værn.
I denne forbindelse observerede forskerne bag det nye studie, at der var en større risiko for at få tilbagefald efter en brystkræftbehandling, hvis blodets niveau af GPX-3 var lavt. Forskerne henviser også til, at brystkræft normalt hænger sammen med oxidativ stress forårsaget af frie radikaler.
Det nye svensk-tyske studie er publiceret i Redox Biology. Det er blandt andet i tråd med et tidligere polsk studie omtalt på denne hjemmeside, som afslørede, at høje selenniveauer i blodet øger chancen for at overleve brystkræft efter 10 år.
Det er i det hele taget vigtigt, at vi er velforsynet med selen gennem hele livet.

Selenmangel er udbredt i Europa, men det kan der kompenseres for

Selenmangel er udbredt i Europa. Især på grund af udpint jord, som afspejler sig i hele fødekæden. Som nævnt bruges selenoprotein P som markør for blodets selenstatus, og undersøgelser viser, at man skal have omkring 100 mikrogram selen om dagen for at mætte selenoprotein P. Denne mængde er omkring det dobbelte af de officielle anbefalinger, RI, som er sat til 55 mikrogram.
Tilskud med selengær, der indeholder mange selenoproteiner, giver også en større lighed med selenvariationen i selenrig kost.
I flere kræftstudier har man givet tilskud på 200 mikrogram. Ifølge EFSA, den Europæiske Fødevaresikkerhedsautoritet, ligger den øvre grænse på 300 mikrogram selen daglig.

Referencer:

Kamil Demircan et al. Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study. Redox Biology, November, 2021

Mark Szwiec et al. Serum Selenium Level Predicts 10-Year Survival after Breast Cancer. Nutrients, March, 2021

Lutz Shomburg. Dietary Selenium and Human Health. Nutrients 2017

New Links between selenium and cancer prevention. HRB. December 2017

  • Oprettet den .
8.674MBMemory Usage779msRequest Duration
Joomla! Version4.4.4
PHP Version8.3.6
Identityguest
Response200
Templateyootheme
Database
Server
mysql
Version
8.0.40-0ubuntu0.24.04.1
Collation
latin1_swedish_ci
Conn Collation
utf8mb4_0900_ai_ci
$_GET
[]
$_POST
[]
$_SESSION
array:1 [ "joomla" => "***redacted***" ]
$_COOKIE
[]
$_SERVER
array:46 [ "REDIRECT_HTTP_AUTHORIZATION" => "" "REDIRECT_HTTPS" => "on" "REDIRECT_SSL_TLS_SNI"...
session
array:3 [ "counter" => 1 "timer" => array:3 [ "start" => 1738273536 "last" => 1738273536...
registry
array:3 [ "data" => [] "initialized" => false "separator" => "." ]
user
array:18 [ "id" => 0 "name" => null "username" => null "email" => null "password" => "***r...
plg_system_languagefilter
array:1 [ "language" => "da-DK" ]
  • afterLoad (456.44KB) (1.45ms)
  • afterInitialise (1.27MB) (50.62ms)
  • afterRoute (603.19KB) (13.36ms)
  • beforeRenderComponent com_content (22.98KB) (1.03ms)
  • Before Access::preloadComponents (all components) (36.09KB) (3.04ms)
  • After Access::preloadComponents (all components) (97.34KB) (1.23ms)
  • Before Access::preloadPermissions (com_content) (1.6KB) (14μs)
  • After Access::preloadPermissions (com_content) (3.19MB) (16.57ms)
  • Before Access::getAssetRules (id:6614 name:com_content.article.3271) (130.65KB) (90μs)
  • After Access::getAssetRules (id:6614 name:com_content.article.3271) (7.38KB) (50μs)
  • beforeRenderRawModule mod_custom (Søg mere info...) (1.54MB) (114ms)
  • afterRenderRawModule mod_custom (Søg mere info...) (4.72KB) (243μs)
  • beforeRenderModule mod_custom (Søg mere info...) (720B) (4μs)
  • afterRenderModule mod_custom (Søg mere info...) (4.18KB) (75μs)
  • afterRenderComponent com_content (53.41KB) (52.22ms)
  • Before Access::getAssetRules (id:8 name:com_content) (49.96KB) (4.59ms)
  • After Access::getAssetRules (id:8 name:com_content) (6.17KB) (29μs)
  • afterDispatch (17.71KB) (1.13ms)
  • beforeRenderRawModule mod_articles_category (LÆS MERE...) (32.66KB) (471μs)
  • afterRenderRawModule mod_articles_category (LÆS MERE...) (115.05KB) (203ms)
  • beforeRenderRawModule mod_tags_popular (Søg) (5.3KB) (28μs)
  • afterRenderRawModule mod_tags_popular (Søg) (25.07KB) (285ms)
  • beforeRenderModule mod_articles_category (LÆS MERE...) (271.75KB) (4.3ms)
  • afterRenderModule mod_articles_category (LÆS MERE...) (1.25KB) (59μs)
  • beforeRenderModule mod_tags_popular (Søg) (5.66KB) (15μs)
  • afterRenderModule mod_tags_popular (Søg) (1.27KB) (26μs)
  • beforeRenderRawModule mod_menu (Main Menu - Dansk) (11.89KB) (195μs)
  • afterRenderRawModule mod_menu (Main Menu - Dansk) (208.48KB) (3.41ms)
  • beforeRenderModule mod_menu (Main Menu - Dansk) (720B) (6μs)
  • afterRenderModule mod_menu (Main Menu - Dansk) (5.36KB) (58μs)
  • beforeRenderRawModule mod_languages (Sprogskift) (4.44KB) (20μs)
  • afterRenderRawModule mod_languages (Sprogskift) (25.47KB) (3.91ms)
  • beforeRenderModule mod_languages (Sprogskift) (720B) (6μs)
  • afterRenderModule mod_languages (Sprogskift) (6.56KB) (23μs)
  • beforeRenderRawModule mod_finder () (6.34KB) (12μs)
  • afterRenderRawModule mod_finder () (134.78KB) (6.14ms)
  • beforeRenderModule mod_finder () (704B) (5μs)
  • afterRenderModule mod_finder () (3.29KB) (34μs)
  • beforeRenderRawModule mod_custom () (6.62KB) (142μs)
  • afterRenderRawModule mod_custom () (21.95KB) (863μs)
  • beforeRenderModule mod_custom () (704B) (6μs)
  • afterRenderModule mod_custom () (1.23KB) (49μs)
  • beforeRenderRawModule mod_menu (Main Menu - Dansk) (5.07KB) (105μs)
  • afterRenderRawModule mod_menu (Main Menu - Dansk) (6.52KB) (761μs)
  • beforeRenderModule mod_menu (Main Menu - Dansk) (720B) (3μs)
  • afterRenderModule mod_menu (Main Menu - Dansk) (1.25KB) (42μs)
  • beforeRenderRawModule mod_languages (Sprogskift Mobil) (912B) (16μs)
  • afterRenderRawModule mod_languages (Sprogskift Mobil) (3.89KB) (2.71ms)
  • beforeRenderModule mod_languages (Sprogskift Mobil) (720B) (6μs)
  • afterRenderModule mod_languages (Sprogskift Mobil) (1.27KB) (35μs)
  • beforeRenderRawModule mod_finder () (2.3KB) (11μs)
  • afterRenderRawModule mod_finder () (6.29KB) (570μs)
  • beforeRenderModule mod_finder () (704B) (4μs)
  • afterRenderModule mod_finder () (1.23KB) (43μs)
  • beforeRenderRawModule mod_custom () (8.66KB) (193μs)
  • afterRenderRawModule mod_custom () (944B) (131μs)
  • beforeRenderModule mod_custom () (704B) (3μs)
  • afterRenderModule mod_custom () (2.43KB) (25μs)
  • beforeRenderRawModule mod_custom () (688B) (80μs)
  • afterRenderRawModule mod_custom () (896B) (89μs)
  • beforeRenderModule mod_custom () (704B) (3μs)
  • afterRenderModule mod_custom () (2.71KB) (21μs)
  • afterRender (173.5KB) (5.84ms)
  • 1 x afterRenderRawModule mod_tags_popular (Søg) (25.07KB) (36.63%)
    285.47ms
    1 x afterRenderRawModule mod_articles_category (LÆS MERE...) (115.05KB) (26.02%)
    202.82ms
    1 x beforeRenderRawModule mod_custom (Søg mere info...) (1.54MB) (14.68%)
    114.38ms
    1 x afterRenderComponent com_content (53.41KB) (6.7%)
    52.22ms
    1 x afterInitialise (1.27MB) (6.49%)
    50.62ms
    1 x After Access::preloadPermissions (com_content) (3.19MB) (2.13%)
    16.57ms
    1 x afterRoute (603.19KB) (1.71%)
    13.36ms
    1 x afterRenderRawModule mod_finder () (134.78KB) (0.79%)
    6.14ms
    1 x afterRender (173.5KB) (0.75%)
    5.84ms
    1 x Before Access::getAssetRules (id:8 name:com_content) (49.96KB) (0.59%)
    4.59ms
    1 x beforeRenderModule mod_articles_category (LÆS MERE...) (271.75KB) (0.55%)
    4.30ms
    1 x afterRenderRawModule mod_languages (Sprogskift) (25.47KB) (0.5%)
    3.91ms
    1 x afterRenderRawModule mod_menu (Main Menu - Dansk) (208.48KB) (0.44%)
    3.41ms
    1 x Before Access::preloadComponents (all components) (36.09KB) (0.39%)
    3.04ms
    1 x afterRenderRawModule mod_languages (Sprogskift Mobil) (3.89KB) (0.35%)
    2.71ms
    1 x afterLoad (456.44KB) (0.19%)
    1.45ms
    1 x After Access::preloadComponents (all components) (97.34KB) (0.16%)
    1.23ms
    1 x afterDispatch (17.71KB) (0.14%)
    1.13ms
    1 x beforeRenderComponent com_content (22.98KB) (0.13%)
    1.03ms
    1 x afterRenderRawModule mod_custom () (21.95KB) (0.11%)
    863μs
    1 x afterRenderRawModule mod_menu (Main Menu - Dansk) (6.52KB) (0.1%)
    761μs
    1 x afterRenderRawModule mod_finder () (6.29KB) (0.07%)
    570μs
    1 x beforeRenderRawModule mod_articles_category (LÆS MERE...) (32.66KB) (0.06%)
    471μs
    1 x afterRenderRawModule mod_custom (Søg mere info...) (4.72KB) (0.03%)
    243μs
    1 x beforeRenderRawModule mod_menu (Main Menu - Dansk) (11.89KB) (0.03%)
    195μs
    1 x beforeRenderRawModule mod_custom () (8.66KB) (0.02%)
    193μs
    1 x beforeRenderRawModule mod_custom () (6.62KB) (0.02%)
    142μs
    1 x afterRenderRawModule mod_custom () (944B) (0.02%)
    131μs
    1 x beforeRenderRawModule mod_menu (Main Menu - Dansk) (5.07KB) (0.01%)
    105μs
    1 x Before Access::getAssetRules (id:6614 name:com_content.article.3271) (130.65KB) (0.01%)
    90μs
    1 x afterRenderRawModule mod_custom () (896B) (0.01%)
    89μs
    1 x beforeRenderRawModule mod_custom () (688B) (0.01%)
    80μs
    1 x afterRenderModule mod_custom (Søg mere info...) (4.18KB) (0.01%)
    75μs
    1 x afterRenderModule mod_articles_category (LÆS MERE...) (1.25KB) (0.01%)
    59μs
    1 x afterRenderModule mod_menu (Main Menu - Dansk) (5.36KB) (0.01%)
    58μs
    1 x After Access::getAssetRules (id:6614 name:com_content.article.3271) (7.38KB) (0.01%)
    50μs
    1 x afterRenderModule mod_custom () (1.23KB) (0.01%)
    49μs
    1 x afterRenderModule mod_finder () (1.23KB) (0.01%)
    43μs
    1 x afterRenderModule mod_menu (Main Menu - Dansk) (1.25KB) (0.01%)
    42μs
    1 x afterRenderModule mod_languages (Sprogskift Mobil) (1.27KB) (0%)
    35μs
    1 x afterRenderModule mod_finder () (3.29KB) (0%)
    34μs
    1 x After Access::getAssetRules (id:8 name:com_content) (6.17KB) (0%)
    29μs
    1 x beforeRenderRawModule mod_tags_popular (Søg) (5.3KB) (0%)
    28μs
    1 x afterRenderModule mod_tags_popular (Søg) (1.27KB) (0%)
    26μs
    1 x afterRenderModule mod_custom () (2.43KB) (0%)
    25μs
    1 x afterRenderModule mod_languages (Sprogskift) (6.56KB) (0%)
    23μs
    1 x afterRenderModule mod_custom () (2.71KB) (0%)
    21μs
    1 x beforeRenderRawModule mod_languages (Sprogskift) (4.44KB) (0%)
    20μs
    1 x beforeRenderRawModule mod_languages (Sprogskift Mobil) (912B) (0%)
    16μs
    1 x beforeRenderModule mod_tags_popular (Søg) (5.66KB) (0%)
    15μs
    1 x Before Access::preloadPermissions (com_content) (1.6KB) (0%)
    14μs
    1 x beforeRenderRawModule mod_finder () (6.34KB) (0%)
    12μs
    3 x beforeRenderModule mod_custom () (704B) (0%)
    12μs
    1 x beforeRenderRawModule mod_finder () (2.3KB) (0%)
    11μs
    2 x beforeRenderModule mod_menu (Main Menu - Dansk) (720B) (0%)
    9μs
    2 x beforeRenderModule mod_finder () (704B) (0%)
    9μs
    1 x beforeRenderModule mod_languages (Sprogskift) (720B) (0%)
    6μs
    1 x beforeRenderModule mod_languages (Sprogskift Mobil) (720B) (0%)
    6μs
    1 x beforeRenderModule mod_custom (Søg mere info...) (720B) (0%)
    4μs
45 statements were executed, 9 of which were duplicates, 36 unique617ms1.3MB
  • SELECT @@SESSION.sql_mode;43μs968B/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:334Copy
  • SELECT `data` FROM `has_session` WHERE `session_id` = ?134μs1008BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:261Copy
  • SELECT `session_id` FROM `has_session` WHERE `session_id` = :session_id LIMIT 11.96ms1.3KBParams/libraries/src/Session/MetadataManager.php:187Copy
  • INSERT INTO `has_session` (`session_id`,`guest`,`time`,`userid`,`username`,`client_id`) VALUES (:session_id, :guest, :time, :user_id, :username, :client_id)1.02ms944BParams/libraries/src/Session/MetadataManager.php:260Copy
  • SELECT `extension_id` AS `id`,`element` AS `option`,`params`,`enabled` FROM `has_extensions` WHERE `type` = 'component' AND `state` = 0 AND `enabled` = 1444μs1.61KB/libraries/src/Component/ComponentHelper.php:399Copy
  • SELECT `id`,`rules` FROM `has_viewlevels`2.15ms656B/libraries/src/Access/Access.php:955Copy
  • SELECT `b`.`id` FROM `has_usergroups` AS `a` LEFT JOIN `has_usergroups` AS `b` ON `b`.`lft` <= `a`.`lft` AND `b`.`rgt` >= `a`.`rgt` WHERE `a`.`id` = :guest136μs1.33KBParams/libraries/src/Access/Access.php:868Copy
  • SELECT `folder` AS `type`,`element` AS `name`,`params` AS `params`,`extension_id` AS `id` FROM `has_extensions` WHERE `enabled` = 1 AND `type` = 'plugin' AND `state` IN (0,1) AND `access` IN (:preparedArray1,:preparedArray2) ORDER BY `ordering`4.83ms3.98KBParams/libraries/src/Plugin/PluginHelper.php:294Copy
  • SELECT * FROM `has_languages` WHERE `published` = 1 ORDER BY `ordering` ASC127μs2.33KB/libraries/src/Language/LanguageHelper.php:142Copy
  • SELECT `element`,`name`,`client_id`,`extension_id` FROM `has_extensions` WHERE `type` = 'language' AND `state` = 0 AND `enabled` = 1121μs1008B/libraries/src/Language/LanguageHelper.php:213Copy
  • SELECT * FROM has_rsform_config517μs1.06KB/administrator/components/com_rsform/helpers/config.php:52Copy
  • SELECT `m`.`id`,`m`.`menutype`,`m`.`title`,`m`.`alias`,`m`.`note`,`m`.`link`,`m`.`type`,`m`.`level`,`m`.`language`,`m`.`browserNav`,`m`.`access`,`m`.`params`,`m`.`home`,`m`.`img`,`m`.`template_style_id`,`m`.`component_id`,`m`.`parent_id`,`m`.`path` AS `route`,`e`.`element` AS `component` FROM `has_menu` AS `m` LEFT JOIN `has_extensions` AS `e` ON `m`.`component_id` = `e`.`extension_id` WHERE ( (`m`.`published` = 1 AND `m`.`parent_id` > 0 AND `m`.`client_id` = 0) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :currentDate1)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :currentDate2) ORDER BY `m`.`lft`1.33ms165.8KBParams/libraries/src/Menu/SiteMenu.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray1,:preparedArray2)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`231μs3.92KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `id`,`home`,`template`,`s`.`params`,`inheritable`,`parent` FROM `has_template_styles` AS `s` LEFT JOIN `has_extensions` AS `e` ON `e`.`element` = `s`.`template` AND `e`.`type` = 'template' AND `e`.`client_id` = `s`.`client_id` WHERE `s`.`client_id` = 0 AND `e`.`enabled` = 1272μs848B/administrator/components/com_templates/src/Model/StyleModel.php:773Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `has_assets` WHERE `name` IN (:preparedArray1,:preparedArray2,:preparedArray3,:preparedArray4,:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24,:preparedArray25,:preparedArray26,:preparedArray27,:preparedArray28,:preparedArray29,:preparedArray30,:preparedArray31,:preparedArray32,:preparedArray33,:preparedArray34,:preparedArray35,:preparedArray36,:preparedArray37,:preparedArray38,:preparedArray39,:preparedArray40)392μs7.44KBParams/libraries/src/Access/Access.php:357Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `has_assets` WHERE `name` LIKE :asset OR `name` = :extension OR `parent_id` = 013.18ms397.48KBParams/libraries/src/Access/Access.php:301Copy
  • SHOW FULL COLUMNS FROM `has_content`6.54ms3.02KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:625Copy
  • UPDATE `has_content` SET `hits` = (`hits` + 1) WHERE `id` = '3271'4.45ms48B/libraries/src/Table/Table.php:1325Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `has_content` AS `a` INNER JOIN `has_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `has_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `has_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `has_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `has_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0 AND `a`.`language` IN (:preparedArray1,:preparedArray2)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray3,:preparedArray4)668μs22.19KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`305μs3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `m`.`tag_id`,`t`.* FROM `has_contentitem_tag_map` AS `m` INNER JOIN `has_tags` AS `t` ON `m`.`tag_id` = `t`.`id` WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2) AND `language` IN (:preparedArray3,:preparedArray4)28.53ms4.09KBParams/libraries/src/Helper/TagsHelper.php:388Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`1.77ms3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM has_fields AS a LEFT JOIN `has_languages` AS l ON l.lang_code = a.language LEFT JOIN has_users AS uc ON uc.id=a.checked_out LEFT JOIN has_viewlevels AS ag ON ag.id = a.access LEFT JOIN has_users AS ua ON ua.id = a.created_user_id LEFT JOIN has_fields_groups AS g ON g.id = a.group_id LEFT JOIN `has_fields_categories` AS fc ON fc.field_id = a.id WHERE ( (`a`.`context` = :context AND (`fc`.`category_id` IS NULL OR `fc`.`category_id` IN (:preparedArray1,:preparedArray2,:preparedArray3)) AND `a`.`access` IN (:preparedArray4,:preparedArray5)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray6,:preparedArray7)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform AND `a`.`language` IN (:preparedArray8,:preparedArray9) ORDER BY a.ordering ASC323μs4.81KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id2.39ms1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id65μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `m`.`id`,`m`.`title`,`m`.`module`,`m`.`position`,`m`.`content`,`m`.`showtitle`,`m`.`params`,`mm`.`menuid` FROM `has_modules` AS `m` LEFT JOIN `has_modules_menu` AS `mm` ON `mm`.`moduleid` = `m`.`id` LEFT JOIN `has_extensions` AS `e` ON `e`.`element` = `m`.`module` AND `e`.`client_id` = `m`.`client_id` WHERE ( ( (`m`.`published` = 1 AND `e`.`enabled` = 1 AND `m`.`client_id` = :clientId AND `m`.`access` IN (:preparedArray1,:preparedArray2)) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :publishUp)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :publishDown)) AND (`mm`.`menuid` = :itemId OR `mm`.`menuid` <= 0) AND `m`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY `m`.`position`,`m`.`ordering`21.98ms261.84KBParams/libraries/src/Cache/Controller/CallbackController.php:51Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`catid`,`a`.`language`, CASE WHEN CHAR_LENGTH(`a`.`alias`) != 0 THEN CONCAT_WS(':', `a`.`id`, `a`.`alias`) ELSE a.id END AS `slug`, CASE WHEN CHAR_LENGTH(`cc`.`alias`) != 0 THEN CONCAT_WS(':', `cc`.`id`, `cc`.`alias`) ELSE cc.id END AS `catslug` FROM `has_content` AS `a` LEFT JOIN `has_categories` AS `cc` ON `cc`.`id` = `a`.`catid` WHERE `a`.`catid` = :catid AND `a`.`state` = :state AND `a`.`access` IN (:preparedArray1,:preparedArray2) AND (`publish_up` IS NULL OR `publish_up` <= :nowDate1) AND (`publish_down` IS NULL OR `publish_down` >= :nowDate2) AND `a`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END DESC41.96ms161.75KBParams/plugins/content/pagenavigation/src/Extension/PageNavigation.php:188Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`312μs3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT custom_data FROM has_extensions WHERE element = 'yootheme' AND folder = 'system' LIMIT 1122μs536B/templates/yootheme/packages/platform-joomla/src/Storage.php:30Copy
  • SELECT `language`,`id` FROM `has_menu` WHERE `home` = '1' AND `published` = 1 AND `client_id` = 0307μs704B/libraries/src/Language/Multilanguage.php:123Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id89μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id172μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid` FROM `has_content` AS `c` INNER JOIN `has_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `has_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `has_content` AS `c2` ON `a2`.`id` = `c2`.`id` INNER JOIN `has_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2 WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'da-DK' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-01-30 21:45:36') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-01-30 21:45:36') AND c2.state = 1273μs3.97KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`,( SELECT COUNT(`i`.`id`) FROM `has_content` AS `i` WHERE `i`.`catid` = `c`.`id` AND `i`.`state` = 1 AND `i`.`language` IN (:preparedArray5,:preparedArray6)) AS `numitems` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`36.52ms4.05KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END AS `publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`metadata`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`featured`,`a`.`language`,LENGTH(`a`.`fulltext`) AS `readmore`,`a`.`ordering`,`fp`.`featured_up`,`fp`.`featured_down`,CASE WHEN `c`.`published` = 2 AND `a`.`state` > 0 THEN 2 WHEN `c`.`published` != 1 THEN 0 ELSE `a`.`state` END AS `state`,`c`.`title` AS `category_title`,`c`.`path` AS `category_route`,`c`.`access` AS `category_access`,`c`.`alias` AS `category_alias`,`c`.`language` AS `category_language`,`c`.`published`,`c`.`published` AS `parents_published`,`c`.`lft`,CASE WHEN `a`.`created_by_alias` > ' ' THEN `a`.`created_by_alias` ELSE `ua`.`name` END AS `author`,`ua`.`email` AS `author_email`,`uam`.`name` AS `modified_by_name`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,COALESCE(NULLIF(ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1), 0), 0) AS `rating`,COALESCE(NULLIF(`v`.`rating_count`, 0), 0) AS `rating_count` FROM `has_content` AS `a` LEFT JOIN `has_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `has_users` AS `ua` ON `ua`.`id` = `a`.`created_by` LEFT JOIN `has_users` AS `uam` ON `uam`.`id` = `a`.`modified_by` LEFT JOIN `has_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `has_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `has_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND `a`.`catid` IN (:preparedArray5) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`language` IN (:preparedArray6,:preparedArray7) ORDER BY RAND() ASC LIMIT 15158ms239.28KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT MAX(`tag_id`) AS `tag_id`,COUNT(*) AS `count`,MAX(`t`.`title`) AS `title`,MAX(`t`.`access`) AS `access`,MAX(`t`.`alias`) AS `alias`,MAX(`t`.`params`) AS `params`,MAX(`t`.`language`) AS `language` FROM `has_contentitem_tag_map` AS `m` INNER JOIN `has_ucm_content` AS `ucm` ON `m`.`content_item_id` = `ucm`.`core_content_item_id` AND `m`.`type_id` = `ucm`.`core_type_id` INNER JOIN `has_categories` AS `cat` ON `ucm`.`core_catid` = `cat`.`id` INNER JOIN `has_tags` AS `t` ON `tag_id` = `t`.`id` INNER JOIN `has_ucm_content` AS `c` ON `m`.`core_content_id` = `c`.`core_content_id` WHERE `t`.`access` IN (:preparedArray1,:preparedArray2) AND `t`.`published` = 1 AND `cat`.`published` > 0 AND `t`.`language` IN (:preparedArray3,:preparedArray4) AND `m`.`type_alias` = `c`.`core_type_alias` AND `c`.`core_state` = 1 AND (`c`.`core_access` IN (:preparedArray5,:preparedArray6) OR `c`.`core_access` = 0) AND (`c`.`core_publish_up` IS NULL OR `c`.`core_publish_up` = :nullDate2 OR `c`.`core_publish_up` <= :nowDate2) AND (`c`.`core_publish_down` IS NULL OR `c`.`core_publish_down` = :nullDate3 OR `c`.`core_publish_down` >= :nowDate3) GROUP BY `tag_id`,`t`.`title`,`t`.`access`,`t`.`alias` ORDER BY RAND() LIMIT 15281ms2.75KBParams/modules/mod_tags_popular/src/Helper/TagsPopularHelper.php:183Copy
  • SELECT `c2`.`language`,`c2`.`id` FROM `has_menu` AS `c` INNER JOIN `has_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `has_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `has_menu` AS `c2` ON `a2`.`id` = `c2`.`id` WHERE `c`.`id` = :id237μs1.44KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT `name`,`element` FROM `has_extensions` WHERE `type` = 'plugin' AND `folder` = 'finder' AND `enabled` = 1200μs640B/administrator/components/com_finder/src/Helper/LanguageHelper.php:135Copy
  • SELECT `title` FROM `has_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1,5)1.11ms584B/administrator/components/com_finder/src/Indexer/Taxonomy.php:314Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM has_fields AS a LEFT JOIN `has_languages` AS l ON l.lang_code = a.language LEFT JOIN has_users AS uc ON uc.id=a.checked_out LEFT JOIN has_viewlevels AS ag ON ag.id = a.access LEFT JOIN has_users AS ua ON ua.id = a.created_user_id LEFT JOIN has_fields_groups AS g ON g.id = a.group_id WHERE ( (`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform AND `a`.`language` IN (:preparedArray5,:preparedArray6) ORDER BY a.ordering ASC325μs4.75KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `title` FROM `has_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1,5)141μs584B/administrator/components/com_finder/src/Indexer/Taxonomy.php:314Copy
  • SELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count FROM `has_scheduler_tasks` AS `a` WHERE `a`.`state` = 1136μs1.37KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:466Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`318μs4KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `session_id` FROM `has_session` WHERE `session_id` = ?102μs1KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291Copy
  • UPDATE `has_session` SET `data` = ? , `time` = ? WHERE `session_id` = ?1.24ms592BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy