Skip to main content

Variant af B3-vitamin booster produktion af blodceller ved kræftbehandling

Variant af B3-vitamin booster produktion af blodceller ved kræftbehandlingForskere fra Schweiz har fundet, at man ved at supplere kosten med en variant af B3-vitamin kaldet nikotinamid ribosid kan øge produktionen af blodceller ved at forbedre deres stamceller. Dette kan hjælpe med at løse alvorlige problemer med blodmangel som følge af stamcellebaserede terapier ved leukæmi og aggressive lymfomer.

Stamcelleterapier bliver mere og mere udbredt, især ved behandling af blodkræft som leukæmi og lymfom. I disse tilfælde fjernes patientens kræftangrebne blodstamceller, som erstattes med nye sunde stamceller. Men omkring en fjerdedel af patienterne dør, fordi den nye produktion af blodceller er for langsom.
Ifølge forskere fra EPFL og UNIL/Ludwig Cancer Research i Schweiz kan en løsning på dette problem være at øge delingen af de såkaldte hæmatopoietiske stamceller, også kaldet HSC´er. Det er nemlig disse stamceller, der producerer de røde og hvide blodlegemer i vores kroppe. Spørgsmålet er bare, hvordan man øger delingen af disse HSC´er.

  • Stamceller er ikke-specialiserede celler
  • De har dog evnen til at modnes til flere specialiserede celletyper som for eksempel diverse blodceller
  • Derfor er der store forhåbninger til stamcellernes medicinske rolle

Nikotinamid ribosid øger stamcellers produktion af nye blodceller

Forskerne ved allerede, at stress bremser HSC´erne. Det er også meget overvældende for kroppen at skulle rekonstruere hele blodcellesystemet, når de syge blodstamceller er fjernet. Denne form for stress forårsager blandt andet en øget aktivitet i cellernes mitokondrier, som er cellernes energiproducerende kraftværker.
For at imødekomme de større krav til genopbygning af blodcellerne, øger mitokondrierne fra HSC´erne en proces, som kaldes for oxidativ phosphylering, og det er denne proces som frembringer energi i form af ATP til cellerne. Men det enorme pres på mitokondrierne bevirker, at de bliver ældet og udslidte i utide.
På baggrund af denne viden har teamet af forskere fra Ludwig Cancer Research nu fundet, at en variant af B3-vitamin kaldet nikotinamid ribosid kan øge aktiviteten i HSC´erne. Undersøgelsen, som også involverede laboratorier fra EPFL´s Institute of Bioengineering og Universitetshospitalet i Lausanne, har betydelige konsekvenser for patienter, der modtager stamcelleterapi. Især fordi nikotinamid ribosid kan tages som et enkelt kosttilskud.

Forbedret funktion af HCS stamceller og øget overlevelse

Da forskerne undersøgte virkningerne af nikotinamid ribosid in vitro (i reagensglas) i museceller og humane celler, fandt de en forbedret funktion af HCS´rne, og at stressede, udslidte mitokondrier hurtigere blev erstattet af nye friske mitokondrier.
Forskerne udsatte desuden mus for stråling, der fjernede deres blodceller, og her fandt forskerne, at musenes chance for at overleve blev forøget med 80 procent, når de samtidig blev behandlet med nikotinamid ribosid. Dette skyldtes en øget gendannelse af røde og hvide blodlegemer.

Nikotinamid ribosid har en signifikant evne til at øge blodgendannelse

Det nye studie betyder alt i alt, at nikotinamid ribosid har en signifikant evne til at forbedre HCS´ernes produktion af nye blodlegemer, hvilket også inkluderer en forbedring af mitokondriernes energiomsætning i cellerne. Undersøgelsen viser således for første gang, at nikotinamid ribosid som kosttilskud kan have en signifikant positiv effekt på forebyggelse af blodgendannelsesproblemer hos kræftpatienter, selv efter kemo og stråling.
Forskerne forventer derfor, at nikotinamid ribosid og andre tilskud, der kan øge stamcellernes sundhed og bloddannelse, inddrages som en komplementær behandling hos kræftpatienter, som mangler blodceller. Der er således tale om en meget enkel og billig behandling, som har potentiale til at forbedre livskvaliteten og redde liv.

Fakta om B3-vitamins varianter

  • B3-vitamin inkluderer tre former: nikotinamid, niacin og nikotinamid ribosid.
  • Alle tre former kan omdannes til NAD+ (nikotinamid adenine dinucleotide)
  • NAD+ er et co-enzym, der er involveret i energiomsætning, reparation af DNA og mange andre biokemiske processer.

Reference:

Vitamin B3 analogue boost production of bloodcells. Ecancernews. 08 Mar 2019

https://en.wikipedia.org/wiki/Vitamin_B3

https://da.wikipedia.org/wiki/Stamcelle

  • Oprettet den .
8.683MBMemory Usage181msRequest Duration
Joomla! Version4.4.4
PHP Version8.3.6
Identityguest
Response200
Templateyootheme
Database
Server
mysql
Version
8.0.40-0ubuntu0.24.04.1
Collation
latin1_swedish_ci
Conn Collation
utf8mb4_0900_ai_ci
$_GET
[]
$_POST
[]
$_SESSION
array:1 [ "joomla" => "***redacted***" ]
$_COOKIE
array:1 [ "8c48c4b25e7bfaf1e1e1af15958abb70" => "sb9veejtfdhlaekvlnvcnv58am" ]
$_SERVER
array:47 [ "REDIRECT_HTTP_AUTHORIZATION" => "" "REDIRECT_HTTPS" => "on" "REDIRECT_SSL_TLS_SNI"...
session
array:3 [ "counter" => 3 "timer" => array:3 [ "start" => 1738270302 "last" => 1738270306...
registry
array:3 [ "data" => [] "initialized" => false "separator" => "." ]
user
array:18 [ "id" => 0 "name" => null "username" => null "email" => null "password" => "***r...
plg_system_languagefilter
array:1 [ "language" => "da-DK" ]
  • afterLoad (456.69KB) (1.15ms)
  • afterInitialise (1.28MB) (15.03ms)
  • afterRoute (602.66KB) (4.25ms)
  • beforeRenderComponent com_content (22.98KB) (453μs)
  • Before Access::preloadComponents (all components) (36.09KB) (342μs)
  • After Access::preloadComponents (all components) (97.34KB) (831μs)
  • Before Access::preloadPermissions (com_content) (1.6KB) (20μs)
  • After Access::preloadPermissions (com_content) (3.19MB) (5.25ms)
  • Before Access::getAssetRules (id:4202 name:com_content.article.2074) (130.65KB) (101μs)
  • After Access::getAssetRules (id:4202 name:com_content.article.2074) (7.38KB) (59μs)
  • beforeRenderRawModule mod_custom (GO GOOGLE) (1.55MB) (23.1ms)
  • afterRenderRawModule mod_custom (GO GOOGLE) (4.72KB) (310μs)
  • beforeRenderModule mod_custom (GO GOOGLE) (720B) (5μs)
  • afterRenderModule mod_custom (GO GOOGLE) (5.93KB) (94μs)
  • afterRenderComponent com_content (51.48KB) (13.44ms)
  • Before Access::getAssetRules (id:8 name:com_content) (50.12KB) (2.21ms)
  • After Access::getAssetRules (id:8 name:com_content) (6.17KB) (59μs)
  • afterDispatch (17.66KB) (756μs)
  • beforeRenderRawModule mod_articles_category (LÆS MERE...) (32.66KB) (548μs)
  • afterRenderRawModule mod_articles_category (LÆS MERE...) (119.58KB) (46.55ms)
  • beforeRenderRawModule mod_tags_popular (Søg) (5.3KB) (32μs)
  • afterRenderRawModule mod_tags_popular (Søg) (20.43KB) (48.93ms)
  • beforeRenderModule mod_articles_category (LÆS MERE...) (271.75KB) (2.32ms)
  • afterRenderModule mod_articles_category (LÆS MERE...) (1.25KB) (65μs)
  • beforeRenderModule mod_tags_popular (Søg) (5.66KB) (15μs)
  • afterRenderModule mod_tags_popular (Søg) (1.27KB) (24μs)
  • beforeRenderRawModule mod_menu (Main Menu - Dansk) (11.89KB) (197μs)
  • afterRenderRawModule mod_menu (Main Menu - Dansk) (208.48KB) (1.76ms)
  • beforeRenderModule mod_menu (Main Menu - Dansk) (720B) (5μs)
  • afterRenderModule mod_menu (Main Menu - Dansk) (5.36KB) (56μs)
  • beforeRenderRawModule mod_languages (Sprogskift) (4.44KB) (18μs)
  • afterRenderRawModule mod_languages (Sprogskift) (25.56KB) (1.84ms)
  • beforeRenderModule mod_languages (Sprogskift) (720B) (7μs)
  • afterRenderModule mod_languages (Sprogskift) (6.56KB) (45μs)
  • beforeRenderRawModule mod_finder () (6.34KB) (14μs)
  • afterRenderRawModule mod_finder () (134.78KB) (2.22ms)
  • beforeRenderModule mod_finder () (704B) (7μs)
  • afterRenderModule mod_finder () (3.29KB) (45μs)
  • beforeRenderRawModule mod_custom () (6.62KB) (196μs)
  • afterRenderRawModule mod_custom () (21.95KB) (1ms)
  • beforeRenderModule mod_custom () (704B) (7μs)
  • afterRenderModule mod_custom () (1.23KB) (54μs)
  • beforeRenderRawModule mod_menu (Main Menu - Dansk) (5.07KB) (116μs)
  • afterRenderRawModule mod_menu (Main Menu - Dansk) (6.52KB) (848μs)
  • beforeRenderModule mod_menu (Main Menu - Dansk) (720B) (4μs)
  • afterRenderModule mod_menu (Main Menu - Dansk) (1.25KB) (49μs)
  • beforeRenderRawModule mod_languages (Sprogskift Mobil) (912B) (18μs)
  • afterRenderRawModule mod_languages (Sprogskift Mobil) (3.89KB) (725μs)
  • beforeRenderModule mod_languages (Sprogskift Mobil) (720B) (4μs)
  • afterRenderModule mod_languages (Sprogskift Mobil) (1.27KB) (29μs)
  • beforeRenderRawModule mod_finder () (2.3KB) (10μs)
  • afterRenderRawModule mod_finder () (6.29KB) (633μs)
  • beforeRenderModule mod_finder () (704B) (6μs)
  • afterRenderModule mod_finder () (1.23KB) (48μs)
  • beforeRenderRawModule mod_custom () (8.66KB) (189μs)
  • afterRenderRawModule mod_custom () (944B) (141μs)
  • beforeRenderModule mod_custom () (704B) (3μs)
  • afterRenderModule mod_custom () (2.43KB) (25μs)
  • beforeRenderRawModule mod_custom () (688B) (81μs)
  • afterRenderRawModule mod_custom () (896B) (91μs)
  • beforeRenderModule mod_custom () (704B) (3μs)
  • afterRenderModule mod_custom () (2.71KB) (22μs)
  • afterRender (173.33KB) (3.14ms)
  • 1 x afterRenderRawModule mod_tags_popular (Søg) (20.43KB) (27.05%)
    48.93ms
    1 x afterRenderRawModule mod_articles_category (LÆS MERE...) (119.58KB) (25.73%)
    46.55ms
    1 x beforeRenderRawModule mod_custom (GO GOOGLE) (1.55MB) (12.76%)
    23.10ms
    1 x afterInitialise (1.28MB) (8.31%)
    15.03ms
    1 x afterRenderComponent com_content (51.48KB) (7.43%)
    13.44ms
    1 x After Access::preloadPermissions (com_content) (3.19MB) (2.9%)
    5.25ms
    1 x afterRoute (602.66KB) (2.35%)
    4.25ms
    1 x afterRender (173.33KB) (1.74%)
    3.14ms
    1 x beforeRenderModule mod_articles_category (LÆS MERE...) (271.75KB) (1.28%)
    2.32ms
    1 x afterRenderRawModule mod_finder () (134.78KB) (1.22%)
    2.22ms
    1 x Before Access::getAssetRules (id:8 name:com_content) (50.12KB) (1.22%)
    2.21ms
    1 x afterRenderRawModule mod_languages (Sprogskift) (25.56KB) (1.02%)
    1.84ms
    1 x afterRenderRawModule mod_menu (Main Menu - Dansk) (208.48KB) (0.97%)
    1.76ms
    1 x afterLoad (456.69KB) (0.64%)
    1.15ms
    1 x afterRenderRawModule mod_custom () (21.95KB) (0.55%)
    1.00ms
    1 x afterRenderRawModule mod_menu (Main Menu - Dansk) (6.52KB) (0.47%)
    848μs
    1 x After Access::preloadComponents (all components) (97.34KB) (0.46%)
    831μs
    1 x afterDispatch (17.66KB) (0.42%)
    756μs
    1 x afterRenderRawModule mod_languages (Sprogskift Mobil) (3.89KB) (0.4%)
    725μs
    1 x afterRenderRawModule mod_finder () (6.29KB) (0.35%)
    633μs
    1 x beforeRenderRawModule mod_articles_category (LÆS MERE...) (32.66KB) (0.3%)
    548μs
    1 x beforeRenderComponent com_content (22.98KB) (0.25%)
    453μs
    1 x Before Access::preloadComponents (all components) (36.09KB) (0.19%)
    342μs
    1 x afterRenderRawModule mod_custom (GO GOOGLE) (4.72KB) (0.17%)
    310μs
    1 x beforeRenderRawModule mod_menu (Main Menu - Dansk) (11.89KB) (0.11%)
    197μs
    1 x beforeRenderRawModule mod_custom () (6.62KB) (0.11%)
    196μs
    1 x beforeRenderRawModule mod_custom () (8.66KB) (0.1%)
    189μs
    1 x afterRenderRawModule mod_custom () (944B) (0.08%)
    141μs
    1 x beforeRenderRawModule mod_menu (Main Menu - Dansk) (5.07KB) (0.06%)
    116μs
    1 x Before Access::getAssetRules (id:4202 name:com_content.article.2074) (130.65KB) (0.06%)
    101μs
    1 x afterRenderModule mod_custom (GO GOOGLE) (5.93KB) (0.05%)
    94μs
    1 x afterRenderRawModule mod_custom () (896B) (0.05%)
    91μs
    1 x beforeRenderRawModule mod_custom () (688B) (0.04%)
    81μs
    1 x afterRenderModule mod_articles_category (LÆS MERE...) (1.25KB) (0.04%)
    65μs
    1 x After Access::getAssetRules (id:4202 name:com_content.article.2074) (7.38KB) (0.03%)
    59μs
    1 x After Access::getAssetRules (id:8 name:com_content) (6.17KB) (0.03%)
    59μs
    1 x afterRenderModule mod_menu (Main Menu - Dansk) (5.36KB) (0.03%)
    56μs
    1 x afterRenderModule mod_custom () (1.23KB) (0.03%)
    54μs
    1 x afterRenderModule mod_menu (Main Menu - Dansk) (1.25KB) (0.03%)
    49μs
    1 x afterRenderModule mod_finder () (1.23KB) (0.03%)
    48μs
    1 x afterRenderModule mod_finder () (3.29KB) (0.02%)
    45μs
    1 x afterRenderModule mod_languages (Sprogskift) (6.56KB) (0.02%)
    45μs
    1 x beforeRenderRawModule mod_tags_popular (Søg) (5.3KB) (0.02%)
    32μs
    1 x afterRenderModule mod_languages (Sprogskift Mobil) (1.27KB) (0.02%)
    29μs
    1 x afterRenderModule mod_custom () (2.43KB) (0.01%)
    25μs
    1 x afterRenderModule mod_tags_popular (Søg) (1.27KB) (0.01%)
    24μs
    1 x afterRenderModule mod_custom () (2.71KB) (0.01%)
    22μs
    1 x Before Access::preloadPermissions (com_content) (1.6KB) (0.01%)
    20μs
    1 x beforeRenderRawModule mod_languages (Sprogskift Mobil) (912B) (0.01%)
    18μs
    1 x beforeRenderRawModule mod_languages (Sprogskift) (4.44KB) (0.01%)
    18μs
    1 x beforeRenderModule mod_tags_popular (Søg) (5.66KB) (0.01%)
    15μs
    1 x beforeRenderRawModule mod_finder () (6.34KB) (0.01%)
    14μs
    2 x beforeRenderModule mod_finder () (704B) (0.01%)
    13μs
    3 x beforeRenderModule mod_custom () (704B) (0.01%)
    13μs
    1 x beforeRenderRawModule mod_finder () (2.3KB) (0.01%)
    10μs
    2 x beforeRenderModule mod_menu (Main Menu - Dansk) (720B) (0.01%)
    9μs
    1 x beforeRenderModule mod_languages (Sprogskift) (720B) (0%)
    7μs
    1 x beforeRenderModule mod_custom (GO GOOGLE) (720B) (0%)
    5μs
    1 x beforeRenderModule mod_languages (Sprogskift Mobil) (720B) (0%)
    4μs
45 statements were executed, 9 of which were duplicates, 36 unique126ms1.32MB
  • SELECT @@SESSION.sql_mode;77μs968B/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:334Copy
  • SELECT `data` FROM `has_session` WHERE `session_id` = ?179μs1KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:261Copy
  • SELECT `session_id` FROM `has_session` WHERE `session_id` = :session_id LIMIT 1111μs1.31KBParams/libraries/src/Session/MetadataManager.php:187Copy
  • UPDATE `has_session` SET `guest` = :guest , `time` = :time , `userid` = :user_id , `username` = :username , `client_id` = :client_id WHERE `session_id` = :session_id2.05ms992BParams/libraries/src/Session/MetadataManager.php:316Copy
  • SELECT `extension_id` AS `id`,`element` AS `option`,`params`,`enabled` FROM `has_extensions` WHERE `type` = 'component' AND `state` = 0 AND `enabled` = 1337μs1.56KB/libraries/src/Component/ComponentHelper.php:399Copy
  • SELECT `id`,`rules` FROM `has_viewlevels`98μs656B/libraries/src/Access/Access.php:955Copy
  • SELECT `b`.`id` FROM `has_usergroups` AS `a` LEFT JOIN `has_usergroups` AS `b` ON `b`.`lft` <= `a`.`lft` AND `b`.`rgt` >= `a`.`rgt` WHERE `a`.`id` = :guest193μs1.33KBParams/libraries/src/Access/Access.php:868Copy
  • SELECT `folder` AS `type`,`element` AS `name`,`params` AS `params`,`extension_id` AS `id` FROM `has_extensions` WHERE `enabled` = 1 AND `type` = 'plugin' AND `state` IN (0,1) AND `access` IN (:preparedArray1,:preparedArray2) ORDER BY `ordering`890μs3.98KBParams/libraries/src/Plugin/PluginHelper.php:294Copy
  • SELECT * FROM `has_languages` WHERE `published` = 1 ORDER BY `ordering` ASC384μs2.33KB/libraries/src/Language/LanguageHelper.php:142Copy
  • SELECT `element`,`name`,`client_id`,`extension_id` FROM `has_extensions` WHERE `type` = 'language' AND `state` = 0 AND `enabled` = 1229μs1008B/libraries/src/Language/LanguageHelper.php:213Copy
  • SELECT * FROM has_rsform_config164μs1.06KB/administrator/components/com_rsform/helpers/config.php:52Copy
  • SELECT `m`.`id`,`m`.`menutype`,`m`.`title`,`m`.`alias`,`m`.`note`,`m`.`link`,`m`.`type`,`m`.`level`,`m`.`language`,`m`.`browserNav`,`m`.`access`,`m`.`params`,`m`.`home`,`m`.`img`,`m`.`template_style_id`,`m`.`component_id`,`m`.`parent_id`,`m`.`path` AS `route`,`e`.`element` AS `component` FROM `has_menu` AS `m` LEFT JOIN `has_extensions` AS `e` ON `m`.`component_id` = `e`.`extension_id` WHERE ( (`m`.`published` = 1 AND `m`.`parent_id` > 0 AND `m`.`client_id` = 0) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :currentDate1)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :currentDate2) ORDER BY `m`.`lft`876μs165.8KBParams/libraries/src/Menu/SiteMenu.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray1,:preparedArray2)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`313μs3.92KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `id`,`home`,`template`,`s`.`params`,`inheritable`,`parent` FROM `has_template_styles` AS `s` LEFT JOIN `has_extensions` AS `e` ON `e`.`element` = `s`.`template` AND `e`.`type` = 'template' AND `e`.`client_id` = `s`.`client_id` WHERE `s`.`client_id` = 0 AND `e`.`enabled` = 1267μs848B/administrator/components/com_templates/src/Model/StyleModel.php:773Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `has_assets` WHERE `name` IN (:preparedArray1,:preparedArray2,:preparedArray3,:preparedArray4,:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24,:preparedArray25,:preparedArray26,:preparedArray27,:preparedArray28,:preparedArray29,:preparedArray30,:preparedArray31,:preparedArray32,:preparedArray33,:preparedArray34,:preparedArray35,:preparedArray36,:preparedArray37,:preparedArray38,:preparedArray39,:preparedArray40)512μs7.44KBParams/libraries/src/Access/Access.php:357Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `has_assets` WHERE `name` LIKE :asset OR `name` = :extension OR `parent_id` = 02.65ms397.48KBParams/libraries/src/Access/Access.php:301Copy
  • SHOW FULL COLUMNS FROM `has_content`781μs3.02KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:625Copy
  • UPDATE `has_content` SET `hits` = (`hits` + 1) WHERE `id` = '2074'1.39ms48B/libraries/src/Table/Table.php:1325Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `has_content` AS `a` INNER JOIN `has_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `has_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `has_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `has_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `has_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0 AND `a`.`language` IN (:preparedArray1,:preparedArray2)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray3,:preparedArray4)371μs22.19KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`355μs3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `m`.`tag_id`,`t`.* FROM `has_contentitem_tag_map` AS `m` INNER JOIN `has_tags` AS `t` ON `m`.`tag_id` = `t`.`id` WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2) AND `language` IN (:preparedArray3,:preparedArray4)4.3ms4.13KBParams/libraries/src/Helper/TagsHelper.php:388Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`376μs3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM has_fields AS a LEFT JOIN `has_languages` AS l ON l.lang_code = a.language LEFT JOIN has_users AS uc ON uc.id=a.checked_out LEFT JOIN has_viewlevels AS ag ON ag.id = a.access LEFT JOIN has_users AS ua ON ua.id = a.created_user_id LEFT JOIN has_fields_groups AS g ON g.id = a.group_id LEFT JOIN `has_fields_categories` AS fc ON fc.field_id = a.id WHERE ( (`a`.`context` = :context AND (`fc`.`category_id` IS NULL OR `fc`.`category_id` IN (:preparedArray1,:preparedArray2,:preparedArray3)) AND `a`.`access` IN (:preparedArray4,:preparedArray5)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray6,:preparedArray7)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform AND `a`.`language` IN (:preparedArray8,:preparedArray9) ORDER BY a.ordering ASC351μs4.81KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id124μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id83μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `m`.`id`,`m`.`title`,`m`.`module`,`m`.`position`,`m`.`content`,`m`.`showtitle`,`m`.`params`,`mm`.`menuid` FROM `has_modules` AS `m` LEFT JOIN `has_modules_menu` AS `mm` ON `mm`.`moduleid` = `m`.`id` LEFT JOIN `has_extensions` AS `e` ON `e`.`element` = `m`.`module` AND `e`.`client_id` = `m`.`client_id` WHERE ( ( (`m`.`published` = 1 AND `e`.`enabled` = 1 AND `m`.`client_id` = :clientId AND `m`.`access` IN (:preparedArray1,:preparedArray2)) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :publishUp)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :publishDown)) AND (`mm`.`menuid` = :itemId OR `mm`.`menuid` <= 0) AND `m`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY `m`.`position`,`m`.`ordering`2.65ms261.84KBParams/libraries/src/Cache/Controller/CallbackController.php:51Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`catid`,`a`.`language`, CASE WHEN CHAR_LENGTH(`a`.`alias`) != 0 THEN CONCAT_WS(':', `a`.`id`, `a`.`alias`) ELSE a.id END AS `slug`, CASE WHEN CHAR_LENGTH(`cc`.`alias`) != 0 THEN CONCAT_WS(':', `cc`.`id`, `cc`.`alias`) ELSE cc.id END AS `catslug` FROM `has_content` AS `a` LEFT JOIN `has_categories` AS `cc` ON `cc`.`id` = `a`.`catid` WHERE `a`.`catid` = :catid AND `a`.`state` = :state AND `a`.`access` IN (:preparedArray1,:preparedArray2) AND (`publish_up` IS NULL OR `publish_up` <= :nowDate1) AND (`publish_down` IS NULL OR `publish_down` >= :nowDate2) AND `a`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END DESC9.98ms161.75KBParams/plugins/content/pagenavigation/src/Extension/PageNavigation.php:188Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`371μs3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT custom_data FROM has_extensions WHERE element = 'yootheme' AND folder = 'system' LIMIT 1147μs536B/templates/yootheme/packages/platform-joomla/src/Storage.php:30Copy
  • SELECT `language`,`id` FROM `has_menu` WHERE `home` = '1' AND `published` = 1 AND `client_id` = 0390μs704B/libraries/src/Language/Multilanguage.php:123Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id110μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id73μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid` FROM `has_content` AS `c` INNER JOIN `has_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `has_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `has_content` AS `c2` ON `a2`.`id` = `c2`.`id` INNER JOIN `has_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2 WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'da-DK' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-01-30 20:51:47') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-01-30 20:51:47') AND c2.state = 1299μs3.97KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`,( SELECT COUNT(`i`.`id`) FROM `has_content` AS `i` WHERE `i`.`catid` = `c`.`id` AND `i`.`state` = 1 AND `i`.`language` IN (:preparedArray5,:preparedArray6)) AS `numitems` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`9.5ms4.05KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END AS `publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`metadata`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`featured`,`a`.`language`,LENGTH(`a`.`fulltext`) AS `readmore`,`a`.`ordering`,`fp`.`featured_up`,`fp`.`featured_down`,CASE WHEN `c`.`published` = 2 AND `a`.`state` > 0 THEN 2 WHEN `c`.`published` != 1 THEN 0 ELSE `a`.`state` END AS `state`,`c`.`title` AS `category_title`,`c`.`path` AS `category_route`,`c`.`access` AS `category_access`,`c`.`alias` AS `category_alias`,`c`.`language` AS `category_language`,`c`.`published`,`c`.`published` AS `parents_published`,`c`.`lft`,CASE WHEN `a`.`created_by_alias` > ' ' THEN `a`.`created_by_alias` ELSE `ua`.`name` END AS `author`,`ua`.`email` AS `author_email`,`uam`.`name` AS `modified_by_name`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,COALESCE(NULLIF(ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1), 0), 0) AS `rating`,COALESCE(NULLIF(`v`.`rating_count`, 0), 0) AS `rating_count` FROM `has_content` AS `a` LEFT JOIN `has_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `has_users` AS `ua` ON `ua`.`id` = `a`.`created_by` LEFT JOIN `has_users` AS `uam` ON `uam`.`id` = `a`.`modified_by` LEFT JOIN `has_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `has_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `has_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND `a`.`catid` IN (:preparedArray5) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`language` IN (:preparedArray6,:preparedArray7) ORDER BY RAND() ASC LIMIT 1534.01ms263.28KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT MAX(`tag_id`) AS `tag_id`,COUNT(*) AS `count`,MAX(`t`.`title`) AS `title`,MAX(`t`.`access`) AS `access`,MAX(`t`.`alias`) AS `alias`,MAX(`t`.`params`) AS `params`,MAX(`t`.`language`) AS `language` FROM `has_contentitem_tag_map` AS `m` INNER JOIN `has_ucm_content` AS `ucm` ON `m`.`content_item_id` = `ucm`.`core_content_item_id` AND `m`.`type_id` = `ucm`.`core_type_id` INNER JOIN `has_categories` AS `cat` ON `ucm`.`core_catid` = `cat`.`id` INNER JOIN `has_tags` AS `t` ON `tag_id` = `t`.`id` INNER JOIN `has_ucm_content` AS `c` ON `m`.`core_content_id` = `c`.`core_content_id` WHERE `t`.`access` IN (:preparedArray1,:preparedArray2) AND `t`.`published` = 1 AND `cat`.`published` > 0 AND `t`.`language` IN (:preparedArray3,:preparedArray4) AND `m`.`type_alias` = `c`.`core_type_alias` AND `c`.`core_state` = 1 AND (`c`.`core_access` IN (:preparedArray5,:preparedArray6) OR `c`.`core_access` = 0) AND (`c`.`core_publish_up` IS NULL OR `c`.`core_publish_up` = :nullDate2 OR `c`.`core_publish_up` <= :nowDate2) AND (`c`.`core_publish_down` IS NULL OR `c`.`core_publish_down` = :nullDate3 OR `c`.`core_publish_down` >= :nowDate3) GROUP BY `tag_id`,`t`.`title`,`t`.`access`,`t`.`alias` ORDER BY RAND() LIMIT 1547.28ms2.75KBParams/modules/mod_tags_popular/src/Helper/TagsPopularHelper.php:183Copy
  • SELECT `c2`.`language`,`c2`.`id` FROM `has_menu` AS `c` INNER JOIN `has_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `has_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `has_menu` AS `c2` ON `a2`.`id` = `c2`.`id` WHERE `c`.`id` = :id304μs1.44KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT `name`,`element` FROM `has_extensions` WHERE `type` = 'plugin' AND `folder` = 'finder' AND `enabled` = 1206μs640B/administrator/components/com_finder/src/Helper/LanguageHelper.php:135Copy
  • SELECT `title` FROM `has_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1,5)147μs584B/administrator/components/com_finder/src/Indexer/Taxonomy.php:314Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM has_fields AS a LEFT JOIN `has_languages` AS l ON l.lang_code = a.language LEFT JOIN has_users AS uc ON uc.id=a.checked_out LEFT JOIN has_viewlevels AS ag ON ag.id = a.access LEFT JOIN has_users AS ua ON ua.id = a.created_user_id LEFT JOIN has_fields_groups AS g ON g.id = a.group_id WHERE ( (`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform AND `a`.`language` IN (:preparedArray5,:preparedArray6) ORDER BY a.ordering ASC331μs4.75KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `title` FROM `has_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1,5)148μs584B/administrator/components/com_finder/src/Indexer/Taxonomy.php:314Copy
  • SELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count FROM `has_scheduler_tasks` AS `a` WHERE `a`.`state` = 1126μs1.37KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:466Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`400μs4KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `session_id` FROM `has_session` WHERE `session_id` = ?116μs1KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291Copy
  • UPDATE `has_session` SET `data` = ? , `time` = ? WHERE `session_id` = ?1.67ms592BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy