Skip to main content

B3-vitamin booster energiomsætning ved muskelsygdomme

B3-vitamin booster energiomsætning ved muskelsygdommeB3-vitamin har en terapeutisk effekt i behandlingen af progressive muskelsygdomme – herunder mitokondrie myopati, der skyldes defekter i cellernes energiomsætning, og hvor der ikke findes effektiv behandling. Det fremgår af et studie fra Helsinki Universitet.

De energigivende stoffer kommer fra madens kulhydrater, fedtstoffer og protein. Selve energiomsætningen foregår ved hjælp af ilt i cellernes kraftværker, som hedder mitokondrier. I første omgang danner mitokondrierne kemisk koncentreret energi i form af ATP. Når der for eksempel skal bruges energi til muskelarbejde eller tankevirksomhed spaltes ATP. Derved frigøres energien. Jo mere energi en celle har brug for, jo flere mitokondrier indeholder den. Derfor indeholder celler i muskler, hjerte og hjerne særlig mange mitokondrier.
Under energiomsætningen spiller de forskellige former af B3-vitamin (niacin) afgørende roller, da de omdannes til coenzymet NAD+ (nikotin-amidadenin-dinukleotid). Således har NAD+ betydning for mitokondriernes metaboliske processer og dannelsen af ATP. NAD+ har desuden betydning for de anabolske (opbyggende) processer samt reparation af ødelagt DNA og mange andre biokemiske processer.

  • B3-vitamin (niacin)
  • B3-vitamin inkluderer flere former
  • Niacin er en fællesbetegnelse for nikotinsyre og nikotinamid
  • Niacin omdannes til NAD+ (nikotinamid adenine dinucleotide)
  • NAD+ er et co-enzym, der er involveret i energiomsætning, reparation af DNA og mange andre biokemiske processer.

B3-vitamin booster NAD+ ved mitokondrie myopati

Det har indtil videre været uvist, hvorvidt der forekommer mangel på NAD+ i sygdomme hos mennesker, og hvorvidt man ved at booste NAD+ kan frembringe en helbredende effekt hos patienter med degenerative sygdomme.
Men nu har en gruppe internationale forskere fra Helsinki Universitet rapporteret, at der er lave forekomster af NAD+ i både blod og muskler hos patienter med mitokondrie myopati.
Mitokondrie myopati er en samlebetegnelse for sygdomme, som er relateret til defekte mitokondrier. Symptomerne er karakteriseret ved, at musklerne gradvist bliver svagere, så førligheden forsvinder. Der kan også forekomme kramper. Indtil videre findes der ingen behandling, som kan forhindre udviklingen. Men nu ser set ud til, at en behandling med B3-vitamin (niacin) har en lovende effekt.
Forskerne fra Helsinki Universitet har nemlig rapporteret, at behandling med niacin kan hæve niveauet af NAD+ hos voksne patienter med mitokondrie myopati. Patienterne fik meget store doser niacin (750-1.000 mg om dagen i op til 10 måneder) med gradvis optrapning.
Behandlingen med niacin var således i stand til at genoprette niveauet af NAD+ i patienternes muskler til et normalt niveau. Behandlingen med niacin kunne også forbedre styrken af patienternes store muskler og mitokondriernes evne til at modstå oxidativ stress. Det er en tilstand, hvor der er en ubalance mellem frie radikaler og antioxidanter, således at de frie radikaler kan angribe celler og mitokondrier.
På flere fronter afslørede studiet, at patienterne fik en mere normal omsætning af energi i deres muskelceller, som var i retning af den raske kontrolgruppe.
Det nye pilotstudie afslører, at de store tilskud med niacin kan være en lovende og billig behandling til patienter med mitokondrie myopati. Ikke desto mindre påpeger forskerne, at behandlingen med niacin kun er relevant, hvis man har observeret en mangel på NAD+ i patienternes blod.
Det nye studie er publiceret i Cell Metabolism.

Kilder til B3-vitamin og årsager til mangler

B3-vitamin findes især i proteinholdige animalske fødevarer som kød, fisk, lever og æg samt peanuts, solsikkefrø, svampe, ærter og avokado.
Mangler og dårlig udnyttelse forårsages af ensidige kostvaner, alkoholmisbrug, aldringsprocesser og længere tids brug af vanddrivende medicin.
Det ser desuden ud til, at mitokondriesygdomme som mitokondrie myopati kan øge behovet.

Referencer:

Eija Pirinen et al. Niacin Cures Systemic NAD deficiency and Improves Muscle Performance in Adult-Onset Mitocondrial Myopathy. Cell Metabolism, 2020

University of Helsinki. Vitamin B3 revitalizes energy metabolism in muscle disease. ScienceDaily. May 14, 2020

https://neuro.dk/wordpress/nnbv/mitokondriemyopati-udredning/

  • Oprettet den .
8.713MBMemory Usage583msRequest Duration
Joomla! Version4.4.4
PHP Version8.3.6
Identityguest
Response200
Templateyootheme
Database
Server
mysql
Version
8.0.40-0ubuntu0.24.04.1
Collation
latin1_swedish_ci
Conn Collation
utf8mb4_0900_ai_ci
$_GET
[]
$_POST
[]
$_SESSION
array:1 [ "joomla" => "***redacted***" ]
$_COOKIE
[]
$_SERVER
array:46 [ "REDIRECT_HTTP_AUTHORIZATION" => "" "REDIRECT_HTTPS" => "on" "REDIRECT_SSL_TLS_SNI"...
session
array:3 [ "counter" => 1 "timer" => array:3 [ "start" => 1742086385 "last" => 1742086385...
registry
array:3 [ "data" => [] "initialized" => false "separator" => "." ]
user
array:18 [ "id" => 0 "name" => null "username" => null "email" => null "password" => "***r...
plg_system_languagefilter
array:1 [ "language" => "da-DK" ]
  • afterLoad (456.34KB) (7.78ms)
  • afterInitialise (1.27MB) (34.43ms)
  • afterRoute (603.19KB) (11.94ms)
  • beforeRenderComponent com_content (22.61KB) (372μs)
  • Before Access::preloadComponents (all components) (36.09KB) (1.6ms)
  • After Access::preloadComponents (all components) (97.34KB) (2.56ms)
  • Before Access::preloadPermissions (com_content) (1.6KB) (16μs)
  • After Access::preloadPermissions (com_content) (3.22MB) (13.89ms)
  • Before Access::getAssetRules (id:5243 name:com_content.article.2586) (130.65KB) (100μs)
  • After Access::getAssetRules (id:5243 name:com_content.article.2586) (7.38KB) (2.02ms)
  • beforeRenderRawModule mod_custom (GO GOOGLE) (1.55MB) (70.59ms)
  • afterRenderRawModule mod_custom (GO GOOGLE) (4.72KB) (3.6ms)
  • beforeRenderModule mod_custom (GO GOOGLE) (720B) (7μs)
  • afterRenderModule mod_custom (GO GOOGLE) (5.93KB) (93μs)
  • afterRenderComponent com_content (51.67KB) (47.96ms)
  • Before Access::getAssetRules (id:8 name:com_content) (49.96KB) (8.24ms)
  • After Access::getAssetRules (id:8 name:com_content) (6.17KB) (27μs)
  • afterDispatch (17.71KB) (597μs)
  • beforeRenderRawModule mod_articles_category (LÆS MERE...) (32.66KB) (427μs)
  • afterRenderRawModule mod_articles_category (LÆS MERE...) (119.42KB) (188ms)
  • beforeRenderRawModule mod_tags_popular (Søg) (5.3KB) (29μs)
  • afterRenderRawModule mod_tags_popular (Søg) (20.48KB) (142ms)
  • beforeRenderModule mod_articles_category (LÆS MERE...) (271.75KB) (4.42ms)
  • afterRenderModule mod_articles_category (LÆS MERE...) (1.25KB) (4.23ms)
  • beforeRenderModule mod_tags_popular (Søg) (5.66KB) (26μs)
  • afterRenderModule mod_tags_popular (Søg) (1.27KB) (43μs)
  • beforeRenderRawModule mod_menu (Main Menu - Dansk) (11.89KB) (212μs)
  • afterRenderRawModule mod_menu (Main Menu - Dansk) (208.48KB) (3.19ms)
  • beforeRenderModule mod_menu (Main Menu - Dansk) (720B) (4μs)
  • afterRenderModule mod_menu (Main Menu - Dansk) (5.36KB) (2.37ms)
  • beforeRenderRawModule mod_languages (Sprogskift) (4.44KB) (20μs)
  • afterRenderRawModule mod_languages (Sprogskift) (25.45KB) (3.45ms)
  • beforeRenderModule mod_languages (Sprogskift) (720B) (4μs)
  • afterRenderModule mod_languages (Sprogskift) (6.56KB) (21μs)
  • beforeRenderRawModule mod_finder () (6.34KB) (9μs)
  • afterRenderRawModule mod_finder () (134.78KB) (7.04ms)
  • beforeRenderModule mod_finder () (704B) (5μs)
  • afterRenderModule mod_finder () (3.29KB) (34μs)
  • beforeRenderRawModule mod_custom () (6.62KB) (138μs)
  • afterRenderRawModule mod_custom () (21.95KB) (1.32ms)
  • beforeRenderModule mod_custom () (704B) (6μs)
  • afterRenderModule mod_custom () (1.23KB) (49μs)
  • beforeRenderRawModule mod_menu (Main Menu - Dansk) (5.07KB) (103μs)
  • afterRenderRawModule mod_menu (Main Menu - Dansk) (6.52KB) (756μs)
  • beforeRenderModule mod_menu (Main Menu - Dansk) (720B) (3μs)
  • afterRenderModule mod_menu (Main Menu - Dansk) (1.25KB) (2.17ms)
  • beforeRenderRawModule mod_languages (Sprogskift Mobil) (912B) (24μs)
  • afterRenderRawModule mod_languages (Sprogskift Mobil) (3.89KB) (653μs)
  • beforeRenderModule mod_languages (Sprogskift Mobil) (720B) (4μs)
  • afterRenderModule mod_languages (Sprogskift Mobil) (1.27KB) (30μs)
  • beforeRenderRawModule mod_finder () (2.3KB) (9μs)
  • afterRenderRawModule mod_finder () (6.29KB) (2.37ms)
  • beforeRenderModule mod_finder () (704B) (5μs)
  • afterRenderModule mod_finder () (1.23KB) (48μs)
  • beforeRenderRawModule mod_custom () (8.66KB) (182μs)
  • afterRenderRawModule mod_custom () (944B) (127μs)
  • beforeRenderModule mod_custom () (704B) (3μs)
  • afterRenderModule mod_custom () (2.43KB) (25μs)
  • beforeRenderRawModule mod_custom () (688B) (85μs)
  • afterRenderRawModule mod_custom () (896B) (90μs)
  • beforeRenderModule mod_custom () (704B) (2μs)
  • afterRenderModule mod_custom () (2.71KB) (22μs)
  • afterRender (173.61KB) (10.52ms)
  • 1 x afterRenderRawModule mod_articles_category (LÆS MERE...) (119.42KB) (32.17%)
    187.55ms
    1 x afterRenderRawModule mod_tags_popular (Søg) (20.48KB) (24.43%)
    142.43ms
    1 x beforeRenderRawModule mod_custom (GO GOOGLE) (1.55MB) (12.11%)
    70.59ms
    1 x afterRenderComponent com_content (51.67KB) (8.22%)
    47.96ms
    1 x afterInitialise (1.27MB) (5.91%)
    34.43ms
    1 x After Access::preloadPermissions (com_content) (3.22MB) (2.38%)
    13.89ms
    1 x afterRoute (603.19KB) (2.05%)
    11.94ms
    1 x afterRender (173.61KB) (1.8%)
    10.52ms
    1 x Before Access::getAssetRules (id:8 name:com_content) (49.96KB) (1.41%)
    8.24ms
    1 x afterLoad (456.34KB) (1.33%)
    7.78ms
    1 x afterRenderRawModule mod_finder () (134.78KB) (1.21%)
    7.04ms
    1 x beforeRenderModule mod_articles_category (LÆS MERE...) (271.75KB) (0.76%)
    4.42ms
    1 x afterRenderModule mod_articles_category (LÆS MERE...) (1.25KB) (0.73%)
    4.23ms
    1 x afterRenderRawModule mod_custom (GO GOOGLE) (4.72KB) (0.62%)
    3.60ms
    1 x afterRenderRawModule mod_languages (Sprogskift) (25.45KB) (0.59%)
    3.45ms
    1 x afterRenderRawModule mod_menu (Main Menu - Dansk) (208.48KB) (0.55%)
    3.19ms
    1 x After Access::preloadComponents (all components) (97.34KB) (0.44%)
    2.56ms
    1 x afterRenderRawModule mod_finder () (6.29KB) (0.41%)
    2.37ms
    1 x afterRenderModule mod_menu (Main Menu - Dansk) (5.36KB) (0.41%)
    2.37ms
    1 x afterRenderModule mod_menu (Main Menu - Dansk) (1.25KB) (0.37%)
    2.17ms
    1 x After Access::getAssetRules (id:5243 name:com_content.article.2586) (7.38KB) (0.35%)
    2.02ms
    1 x Before Access::preloadComponents (all components) (36.09KB) (0.27%)
    1.60ms
    1 x afterRenderRawModule mod_custom () (21.95KB) (0.23%)
    1.32ms
    1 x afterRenderRawModule mod_menu (Main Menu - Dansk) (6.52KB) (0.13%)
    756μs
    1 x afterRenderRawModule mod_languages (Sprogskift Mobil) (3.89KB) (0.11%)
    653μs
    1 x afterDispatch (17.71KB) (0.1%)
    597μs
    1 x beforeRenderRawModule mod_articles_category (LÆS MERE...) (32.66KB) (0.07%)
    427μs
    1 x beforeRenderComponent com_content (22.61KB) (0.06%)
    372μs
    1 x beforeRenderRawModule mod_menu (Main Menu - Dansk) (11.89KB) (0.04%)
    212μs
    1 x beforeRenderRawModule mod_custom () (8.66KB) (0.03%)
    182μs
    1 x beforeRenderRawModule mod_custom () (6.62KB) (0.02%)
    138μs
    1 x afterRenderRawModule mod_custom () (944B) (0.02%)
    127μs
    1 x beforeRenderRawModule mod_menu (Main Menu - Dansk) (5.07KB) (0.02%)
    103μs
    1 x Before Access::getAssetRules (id:5243 name:com_content.article.2586) (130.65KB) (0.02%)
    100μs
    1 x afterRenderModule mod_custom (GO GOOGLE) (5.93KB) (0.02%)
    93μs
    1 x afterRenderRawModule mod_custom () (896B) (0.02%)
    90μs
    1 x beforeRenderRawModule mod_custom () (688B) (0.01%)
    85μs
    1 x afterRenderModule mod_custom () (1.23KB) (0.01%)
    49μs
    1 x afterRenderModule mod_finder () (1.23KB) (0.01%)
    48μs
    1 x afterRenderModule mod_tags_popular (Søg) (1.27KB) (0.01%)
    43μs
    1 x afterRenderModule mod_finder () (3.29KB) (0.01%)
    34μs
    1 x afterRenderModule mod_languages (Sprogskift Mobil) (1.27KB) (0.01%)
    30μs
    1 x beforeRenderRawModule mod_tags_popular (Søg) (5.3KB) (0%)
    29μs
    1 x After Access::getAssetRules (id:8 name:com_content) (6.17KB) (0%)
    27μs
    1 x beforeRenderModule mod_tags_popular (Søg) (5.66KB) (0%)
    26μs
    1 x afterRenderModule mod_custom () (2.43KB) (0%)
    25μs
    1 x beforeRenderRawModule mod_languages (Sprogskift Mobil) (912B) (0%)
    24μs
    1 x afterRenderModule mod_custom () (2.71KB) (0%)
    22μs
    1 x afterRenderModule mod_languages (Sprogskift) (6.56KB) (0%)
    21μs
    1 x beforeRenderRawModule mod_languages (Sprogskift) (4.44KB) (0%)
    20μs
    1 x Before Access::preloadPermissions (com_content) (1.6KB) (0%)
    16μs
    3 x beforeRenderModule mod_custom () (704B) (0%)
    11μs
    2 x beforeRenderModule mod_finder () (704B) (0%)
    10μs
    1 x beforeRenderRawModule mod_finder () (2.3KB) (0%)
    9μs
    1 x beforeRenderRawModule mod_finder () (6.34KB) (0%)
    9μs
    1 x beforeRenderModule mod_custom (GO GOOGLE) (720B) (0%)
    7μs
    2 x beforeRenderModule mod_menu (Main Menu - Dansk) (720B) (0%)
    7μs
    1 x beforeRenderModule mod_languages (Sprogskift) (720B) (0%)
    4μs
    1 x beforeRenderModule mod_languages (Sprogskift Mobil) (720B) (0%)
    4μs
45 statements were executed, 9 of which were duplicates, 36 unique413ms1.28MB
  • SELECT @@SESSION.sql_mode;197μs968B/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:334Copy
  • SELECT `data` FROM `has_session` WHERE `session_id` = ?207μs1008BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:261Copy
  • SELECT `session_id` FROM `has_session` WHERE `session_id` = :session_id LIMIT 1147μs1.3KBParams/libraries/src/Session/MetadataManager.php:187Copy
  • INSERT INTO `has_session` (`session_id`,`guest`,`time`,`userid`,`username`,`client_id`) VALUES (:session_id, :guest, :time, :user_id, :username, :client_id)3.05ms944BParams/libraries/src/Session/MetadataManager.php:260Copy
  • SELECT `extension_id` AS `id`,`element` AS `option`,`params`,`enabled` FROM `has_extensions` WHERE `type` = 'component' AND `state` = 0 AND `enabled` = 1805μs1.61KB/libraries/src/Component/ComponentHelper.php:399Copy
  • SELECT `id`,`rules` FROM `has_viewlevels`94μs656B/libraries/src/Access/Access.php:955Copy
  • SELECT `b`.`id` FROM `has_usergroups` AS `a` LEFT JOIN `has_usergroups` AS `b` ON `b`.`lft` <= `a`.`lft` AND `b`.`rgt` >= `a`.`rgt` WHERE `a`.`id` = :guest308μs1.33KBParams/libraries/src/Access/Access.php:868Copy
  • SELECT `folder` AS `type`,`element` AS `name`,`params` AS `params`,`extension_id` AS `id` FROM `has_extensions` WHERE `enabled` = 1 AND `type` = 'plugin' AND `state` IN (0,1) AND `access` IN (:preparedArray1,:preparedArray2) ORDER BY `ordering`3.13ms3.98KBParams/libraries/src/Plugin/PluginHelper.php:294Copy
  • SELECT * FROM `has_languages` WHERE `published` = 1 ORDER BY `ordering` ASC136μs2.33KB/libraries/src/Language/LanguageHelper.php:142Copy
  • SELECT `element`,`name`,`client_id`,`extension_id` FROM `has_extensions` WHERE `type` = 'language' AND `state` = 0 AND `enabled` = 1301μs1008B/libraries/src/Language/LanguageHelper.php:213Copy
  • SELECT * FROM has_rsform_config150μs1.06KB/administrator/components/com_rsform/helpers/config.php:52Copy
  • SELECT `m`.`id`,`m`.`menutype`,`m`.`title`,`m`.`alias`,`m`.`note`,`m`.`link`,`m`.`type`,`m`.`level`,`m`.`language`,`m`.`browserNav`,`m`.`access`,`m`.`params`,`m`.`home`,`m`.`img`,`m`.`template_style_id`,`m`.`component_id`,`m`.`parent_id`,`m`.`path` AS `route`,`e`.`element` AS `component` FROM `has_menu` AS `m` LEFT JOIN `has_extensions` AS `e` ON `m`.`component_id` = `e`.`extension_id` WHERE ( (`m`.`published` = 1 AND `m`.`parent_id` > 0 AND `m`.`client_id` = 0) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :currentDate1)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :currentDate2) ORDER BY `m`.`lft`2.29ms165.8KBParams/libraries/src/Menu/SiteMenu.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray1,:preparedArray2)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`271μs3.92KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `id`,`home`,`template`,`s`.`params`,`inheritable`,`parent` FROM `has_template_styles` AS `s` LEFT JOIN `has_extensions` AS `e` ON `e`.`element` = `s`.`template` AND `e`.`type` = 'template' AND `e`.`client_id` = `s`.`client_id` WHERE `s`.`client_id` = 0 AND `e`.`enabled` = 11.08ms848B/administrator/components/com_templates/src/Model/StyleModel.php:773Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `has_assets` WHERE `name` IN (:preparedArray1,:preparedArray2,:preparedArray3,:preparedArray4,:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24,:preparedArray25,:preparedArray26,:preparedArray27,:preparedArray28,:preparedArray29,:preparedArray30,:preparedArray31,:preparedArray32,:preparedArray33,:preparedArray34,:preparedArray35,:preparedArray36,:preparedArray37,:preparedArray38,:preparedArray39,:preparedArray40)820μs7.44KBParams/libraries/src/Access/Access.php:357Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `has_assets` WHERE `name` LIKE :asset OR `name` = :extension OR `parent_id` = 06.36ms397.48KBParams/libraries/src/Access/Access.php:301Copy
  • SHOW FULL COLUMNS FROM `has_content`916μs3.02KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:625Copy
  • UPDATE `has_content` SET `hits` = (`hits` + 1) WHERE `id` = '2586'1.86ms48B/libraries/src/Table/Table.php:1325Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `has_content` AS `a` INNER JOIN `has_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `has_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `has_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `has_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `has_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0 AND `a`.`language` IN (:preparedArray1,:preparedArray2)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray3,:preparedArray4)1.2ms22.19KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`324μs3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `m`.`tag_id`,`t`.* FROM `has_contentitem_tag_map` AS `m` INNER JOIN `has_tags` AS `t` ON `m`.`tag_id` = `t`.`id` WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2) AND `language` IN (:preparedArray3,:preparedArray4)12.03ms4.11KBParams/libraries/src/Helper/TagsHelper.php:388Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`392μs3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM has_fields AS a LEFT JOIN `has_languages` AS l ON l.lang_code = a.language LEFT JOIN has_users AS uc ON uc.id=a.checked_out LEFT JOIN has_viewlevels AS ag ON ag.id = a.access LEFT JOIN has_users AS ua ON ua.id = a.created_user_id LEFT JOIN has_fields_groups AS g ON g.id = a.group_id LEFT JOIN `has_fields_categories` AS fc ON fc.field_id = a.id WHERE ( (`a`.`context` = :context AND (`fc`.`category_id` IS NULL OR `fc`.`category_id` IN (:preparedArray1,:preparedArray2,:preparedArray3)) AND `a`.`access` IN (:preparedArray4,:preparedArray5)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray6,:preparedArray7)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform AND `a`.`language` IN (:preparedArray8,:preparedArray9) ORDER BY a.ordering ASC1.11ms4.81KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id369μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id125μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `m`.`id`,`m`.`title`,`m`.`module`,`m`.`position`,`m`.`content`,`m`.`showtitle`,`m`.`params`,`mm`.`menuid` FROM `has_modules` AS `m` LEFT JOIN `has_modules_menu` AS `mm` ON `mm`.`moduleid` = `m`.`id` LEFT JOIN `has_extensions` AS `e` ON `e`.`element` = `m`.`module` AND `e`.`client_id` = `m`.`client_id` WHERE ( ( (`m`.`published` = 1 AND `e`.`enabled` = 1 AND `m`.`client_id` = :clientId AND `m`.`access` IN (:preparedArray1,:preparedArray2)) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :publishUp)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :publishDown)) AND (`mm`.`menuid` = :itemId OR `mm`.`menuid` <= 0) AND `m`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY `m`.`position`,`m`.`ordering`5.82ms261.84KBParams/libraries/src/Cache/Controller/CallbackController.php:51Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`catid`,`a`.`language`, CASE WHEN CHAR_LENGTH(`a`.`alias`) != 0 THEN CONCAT_WS(':', `a`.`id`, `a`.`alias`) ELSE a.id END AS `slug`, CASE WHEN CHAR_LENGTH(`cc`.`alias`) != 0 THEN CONCAT_WS(':', `cc`.`id`, `cc`.`alias`) ELSE cc.id END AS `catslug` FROM `has_content` AS `a` LEFT JOIN `has_categories` AS `cc` ON `cc`.`id` = `a`.`catid` WHERE `a`.`catid` = :catid AND `a`.`state` = :state AND `a`.`access` IN (:preparedArray1,:preparedArray2) AND (`publish_up` IS NULL OR `publish_up` <= :nowDate1) AND (`publish_down` IS NULL OR `publish_down` >= :nowDate2) AND `a`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END DESC39.13ms161.75KBParams/plugins/content/pagenavigation/src/Extension/PageNavigation.php:188Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`328μs3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT custom_data FROM has_extensions WHERE element = 'yootheme' AND folder = 'system' LIMIT 1116μs536B/templates/yootheme/packages/platform-joomla/src/Storage.php:30Copy
  • SELECT `language`,`id` FROM `has_menu` WHERE `home` = '1' AND `published` = 1 AND `client_id` = 01.16ms704B/libraries/src/Language/Multilanguage.php:123Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id1.63ms1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id104μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid` FROM `has_content` AS `c` INNER JOIN `has_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `has_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `has_content` AS `c2` ON `a2`.`id` = `c2`.`id` INNER JOIN `has_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2 WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'da-DK' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-03-16 00:53:05') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-03-16 00:53:05') AND c2.state = 1285μs3.97KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug`,( SELECT COUNT(`i`.`id`) FROM `has_content` AS `i` WHERE `i`.`catid` = `c`.`id` AND `i`.`state` = 1 AND `i`.`language` IN (:preparedArray5,:preparedArray6)) AS `numitems` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`39.17ms4.05KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END AS `publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`metadata`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`featured`,`a`.`language`,LENGTH(`a`.`fulltext`) AS `readmore`,`a`.`ordering`,`fp`.`featured_up`,`fp`.`featured_down`,CASE WHEN `c`.`published` = 2 AND `a`.`state` > 0 THEN 2 WHEN `c`.`published` != 1 THEN 0 ELSE `a`.`state` END AS `state`,`c`.`title` AS `category_title`,`c`.`path` AS `category_route`,`c`.`access` AS `category_access`,`c`.`alias` AS `category_alias`,`c`.`language` AS `category_language`,`c`.`published`,`c`.`published` AS `parents_published`,`c`.`lft`,CASE WHEN `a`.`created_by_alias` > ' ' THEN `a`.`created_by_alias` ELSE `ua`.`name` END AS `author`,`ua`.`email` AS `author_email`,`uam`.`name` AS `modified_by_name`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,COALESCE(NULLIF(ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1), 0), 0) AS `rating`,COALESCE(NULLIF(`v`.`rating_count`, 0), 0) AS `rating_count` FROM `has_content` AS `a` LEFT JOIN `has_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `has_users` AS `ua` ON `ua`.`id` = `a`.`created_by` LEFT JOIN `has_users` AS `uam` ON `uam`.`id` = `a`.`modified_by` LEFT JOIN `has_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `has_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `has_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND `a`.`catid` IN (:preparedArray5) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`language` IN (:preparedArray6,:preparedArray7) ORDER BY RAND() ASC LIMIT 15142ms215.28KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT MAX(`tag_id`) AS `tag_id`,COUNT(*) AS `count`,MAX(`t`.`title`) AS `title`,MAX(`t`.`access`) AS `access`,MAX(`t`.`alias`) AS `alias`,MAX(`t`.`params`) AS `params`,MAX(`t`.`language`) AS `language` FROM `has_contentitem_tag_map` AS `m` INNER JOIN `has_ucm_content` AS `ucm` ON `m`.`content_item_id` = `ucm`.`core_content_item_id` AND `m`.`type_id` = `ucm`.`core_type_id` INNER JOIN `has_categories` AS `cat` ON `ucm`.`core_catid` = `cat`.`id` INNER JOIN `has_tags` AS `t` ON `tag_id` = `t`.`id` INNER JOIN `has_ucm_content` AS `c` ON `m`.`core_content_id` = `c`.`core_content_id` WHERE `t`.`access` IN (:preparedArray1,:preparedArray2) AND `t`.`published` = 1 AND `cat`.`published` > 0 AND `t`.`language` IN (:preparedArray3,:preparedArray4) AND `m`.`type_alias` = `c`.`core_type_alias` AND `c`.`core_state` = 1 AND (`c`.`core_access` IN (:preparedArray5,:preparedArray6) OR `c`.`core_access` = 0) AND (`c`.`core_publish_up` IS NULL OR `c`.`core_publish_up` = :nullDate2 OR `c`.`core_publish_up` <= :nowDate2) AND (`c`.`core_publish_down` IS NULL OR `c`.`core_publish_down` = :nullDate3 OR `c`.`core_publish_down` >= :nowDate3) GROUP BY `tag_id`,`t`.`title`,`t`.`access`,`t`.`alias` ORDER BY RAND() LIMIT 15139ms2.75KBParams/modules/mod_tags_popular/src/Helper/TagsPopularHelper.php:183Copy
  • SELECT `c2`.`language`,`c2`.`id` FROM `has_menu` AS `c` INNER JOIN `has_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `has_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `has_menu` AS `c2` ON `a2`.`id` = `c2`.`id` WHERE `c`.`id` = :id179μs1.44KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT `name`,`element` FROM `has_extensions` WHERE `type` = 'plugin' AND `folder` = 'finder' AND `enabled` = 1172μs640B/administrator/components/com_finder/src/Helper/LanguageHelper.php:135Copy
  • SELECT `title` FROM `has_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1,5)1.95ms584B/administrator/components/com_finder/src/Indexer/Taxonomy.php:314Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM has_fields AS a LEFT JOIN `has_languages` AS l ON l.lang_code = a.language LEFT JOIN has_users AS uc ON uc.id=a.checked_out LEFT JOIN has_viewlevels AS ag ON ag.id = a.access LEFT JOIN has_users AS ua ON ua.id = a.created_user_id LEFT JOIN has_fields_groups AS g ON g.id = a.group_id WHERE ( (`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform AND `a`.`language` IN (:preparedArray5,:preparedArray6) ORDER BY a.ordering ASC292μs4.75KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `title` FROM `has_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1,5)145μs584B/administrator/components/com_finder/src/Indexer/Taxonomy.php:314Copy
  • SELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count FROM `has_scheduler_tasks` AS `a` WHERE `a`.`state` = 1107μs1.37KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:466Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`2ms4KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `session_id` FROM `has_session` WHERE `session_id` = ?89μs1KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291Copy
  • UPDATE `has_session` SET `data` = ? , `time` = ? WHERE `session_id` = ?1.51ms592BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy