Critically ill patients often suffer from inflammation and oxidative stress, which is an imbalance between harmful free radicals and protective antioxidants. In worst case, this may result in tissue damage and organ failure. It turns out vitamin C is a powerful antioxidant with a therapeutic potential. According to a new systematic review article and meta-analysis, therapy with large quantities of intravenous vitamin C helps shorten the duration of the hospital stay for critically ill patients without any side effects.

- even in the case of COVID-19

Vitamin D is important for a well-functioning immune defense and a number of other functions. A team of scientists from Purdue University and National Institutes of Health in the United States has recently uncovered mechanisms that enable vitamin D to reduce hyperinflammation in severe COVID-19 cases. The scientists refer to a particularly active vitamin D metabolite that is formed in immune cells, in the lungs, and various other places. It is important to have adequate levels of vitamin D at all times, and it is equally vital for the body to be able to activate vitamin D, a process that requires the presence of magnesium.

There is worldwide focus on finding better ways to prevent and treat COVID-19 because of the limited effect of vaccines. It is important to understand why the infections are harmless in most cases and why only a small number of people are affected by ARDS (acute respiratory distress syndrome), which is complicated and involves hyperinflammation. What represents the real problem here and what makes these infections life-threatening is a derailed and overactive immune defense. Multiple studies have already demonstrated that lack of vitamin D increases the risk of being infected with COVID-19 ending up in intensive care, and the studies also show that vitamin D supplements have a therapeutic potential. In a new review article that is published in Clinical and Molecular Allergy, researchers look closer at the synergy between vitamin D, magnesium, and zinc in relation to their ability to regulate the immune system and as potential therapeutic agents. It is also vital to have enough selenium, a nutrient that many people lack.

HIV, the virus that causes AIDS, is potentially life-threatening because it attacks central cells in the immune defense. It has also been documented that HIV patients have an increased risk of lacking vitamin D. This can be because of the disease itself, the combination therapy, lack of sun exposure, or other factors. Vitamin D is important for the immune defense, the bones, our mood, and numerous other functions. According to a new article published in MedicalNews Today, it is important to measure HIV patients’ blood levels of vitamin D and possibly give them high-dosed supplements to optimize levels of the nutrient. Earlier studies point to a link between the course of an HIV infections and the body’s selenium status.

- and supplements may have therapeutic value

Hereditary hemochromatosis is a group of diseases that involve iron accumulation in the body. This leads to oxidative stress and tissue destruction which may affect the liver and other organs. According to a new Argentinian study, patients with hereditary hemochromatosis lack Q10 in their blood. Because Q10 is of vital importance to the cellular energy turnover and it also serves as a powerful antioxidant against oxidative stress, a Q10 deficiency will contribute to the disease. This, the researchers behind the new study explain, is why Q10 may represent a new and safe agent for treating the condition.

Migraine is a common neurological disease that reduces quality of life and results in many sick days. Migraine medication does not work for everyone and many people have adverse effects, so it makes more sense to focus on prevention. A new American study shows that diets with higher levels of omega-3 fatty acids from oily fish can reduce the frequency of migraines compared with eating an average diet. People who dislike the taste of fish can take a high-quality fish oil supplement, instead.

When it comes to COVID-19 and other seasonal virus infections most of the focus is concentrated on vitamin D deficiency. According to a Belgian study, however, lack of selenium and zinc additionally increases the risk of infections, complications, and death, especially among patients who already suffer from chronic diseases. The scientists conclude that supplementation with selenium and zinc may help improve treatments. Selenium and zinc deficiencies are rather common and that is a problem for public health. Even with a healthy diet, it is practically impossible for Europeans to get enough selenium because of the nutrient-depleted farmland. There are also many people with zinc deficiencies due to unhealthy diets, ageing, chronic diseases, and other contributing factors. We must be much more focused on getting enough selenium and zinc, not least for the sake of preventing virus infections and other problems.

Vitamin D is essential for the immune defense but many of us are deficient of the nutrient during the dark winter period. The Danish Veterinary and Food Administration therefore recommends for everyone to take a vitamin D supplement in the winter months and that vulnerable population groups supplement all year round. Many people are unaware that being vitamin D-deficient contributes to new waves of COVID-19 and other types of viruses while increasing the risk of infections becoming complicated and life-threatening. This was demonstrated in multiple studies that have been published over the past 18 months. Leading scientists call for immediate action in terms of optimizing vitamin D levels in the population to help fight COVID-19 and other virus infections, simply because vaccines only have limited effect.