Skip to main content

High-dosed vitamin C can help patients with cystic fibrosis

High-dosed vitamin C can help patients with cystic fibrosisCystic fibrosis is a serious condition that affects the respiratory tract. It comes with chronic inflammation and sticky mucous and is known to cause early death. Patients who take high-dosed vitamin C supplements seem to make better use of vitamin E, which is also an antioxidant, and the result is less inflammation. This was seen in a study from Oregon State University. The scientists mention that taking extra vitamin C is also relevant for smokers and patients with metabolic disease.

More than 160,000 people worldwide suffer from cystic fibrosis, a hereditary disease. People suffering from this disease have great difficulty with getting rid of the sticky mucous their glands produce. The mucous can block their airway passage and make it difficult to breathe. There is also a risk of chronic infections that can damage the lungs. Cystic fibrosis is associated with chronic inflammation and oxidative stress, which is an imbalance between free radicals and antioxidants and destroys cells and tissues.
Besides, cystic fibrosis impairs the body’s lipid absorption, which can impair the uptake of vitamin E, one of the very powerful, lipid-soluble antioxidants. The low levels of vitamin E in the blood increase levels of oxidative stress and cause more inflammation that damages the tissues in the airways.
Although conventional therapies have improved, the average life expectancy hovers around 40 years. A team of scientists from Oregon State University therefore wanted to study if high-dosed supplementation with vitamin C could help patients with cystic fibrosis by enabling them to make better use of the vitamin E they had in their blood. As it turns out, vitamin C can recycle oxidized vitamin E, thereby restoring the vitamin’s antioxidant properties. Moreover, vitamin C in itself is a powerful, water-soluble antioxidant that counteracts oxidative stress and chronic inflammation in other ways.

  • Vitamin C and vitamin E work in synergy as an antioxidant team. One is water-soluble, while the other is lipid-soluble.
  • Vitamin C is able to recycle oxidized vitamin E, thereby restoring vitamin E’s antioxidant power and increasing the total antioxidant capacity

Vitamin C improves vitamin E’s potential in cystic fibrosis

The cystic fibrosis patients in the new study, which is published in Nutrients, were given 1,000 mg of vitamin C daily. After three and half weeks, the patients had lower levels of MDA (malondialdehyde), a marker of oxidative stress. It also looked as if vitamin E functioned longer as an antioxidant in their blood.
Vitamin E is lipid-soluble and normally circulates in the blood longer than the water-soluble antioxidants. According to the researchers, this makes vitamin E more able to reach the different tissues and protect the vulnerable, lipid-containing cell membranes against oxidative stress.

Smokers and patients with metabolic syndrome also benefit from taking vitamin C

The results of the new study, the authors say, support earlier research. For example, it has been seen that smokers typically have health issues in their respiratory tract and other places in the body because of oxidative stress. Tobacco smoke generates cascades of free radicals that attack the lung tissue and circulate in the blood. Smokers therefore have an increased need for protective antioxidants such as vitamins C and E.
Metabolic syndrome, an early stage of type 2 diabetes, is also characterized by oxidative stress. This is because of the elevated insulin levels and overweight that tend to cause chronic inflammation and oxidative stress. Patients with metabolic syndrome also have an increased need for vitamin C and vitamin E for that reason.

High-dosed supplements of non-acidic vitamin C

The official recommendations for vitamin C are typically somewhere between 80-100 mg daily. It is possible to reach that amount with a balanced diet. However, in the study of patients with cystic fibrosis, daily doses of 1,000 mg daily were used and is far more than you get from the diet. It would require eating 15 oranges or five medium-sized red bell peppers every day. Just for the record, eating too much fruit is a burden to the blood sugar balance and liver function. A better solution is to supplement an otherwise healthy diet with vitamin C, and when taking such large doses as 1,000 mg daily, it may be a good idea to take a non-acidic form like calcium ascorbate that is gentle on the stomach.

References:

Maret G. Traber, Scott W. Leonard, Vihas T. Vasu, Brian M. Morrissey, Huangshu (John) Lei, Jeffrey Atkinson, Carroll E. Cross. α-Tocopherol Pharmacokinetics in Adults with Cystic Fibrosis: Benefits of Supplemental Vitamin C Administration. Nutrients, 2022

Oregon State University. Cystic fibrosis patients can benefit from vitamin supplements, research shows. ScienceDaily. September 29. 2022

  • Created on .
8.753MBMemory Usage3.64sRequest Duration
Joomla! Version4.4.4
PHP Version8.3.6
Identityguest
Response200
Templateyootheme
Database
Server
mysql
Version
8.0.40-0ubuntu0.24.04.1
Collation
latin1_swedish_ci
Conn Collation
utf8mb4_0900_ai_ci
$_GET
[]
$_POST
[]
$_SESSION
array:1 [ "joomla" => "***redacted***" ]
$_COOKIE
[]
$_SERVER
array:46 [ "REDIRECT_HTTP_AUTHORIZATION" => "" "REDIRECT_HTTPS" => "on" "REDIRECT_SSL_TLS_SNI"...
session
array:3 [ "counter" => 1 "timer" => array:3 [ "start" => 1740247447 "last" => 1740247447...
registry
array:3 [ "data" => [] "initialized" => false "separator" => "." ]
user
array:18 [ "id" => 0 "name" => null "username" => null "email" => null "password" => "***r...
plg_system_languagefilter
array:1 [ "language" => "en-GB" ]
  • afterLoad (456.41KB) (3.53ms)
  • afterInitialise (1.27MB) (70.54ms)
  • afterRoute (897.2KB) (39.88ms)
  • beforeRenderComponent com_content (23.02KB) (12.1ms)
  • Before Access::preloadComponents (all components) (33.23KB) (244μs)
  • After Access::preloadComponents (all components) (97.34KB) (6.76ms)
  • Before Access::preloadPermissions (com_content) (1.6KB) (17μs)
  • After Access::preloadPermissions (com_content) (3.2MB) (76.33ms)
  • Before Access::getAssetRules (id:7531 name:com_content.article.3730) (130.65KB) (121μs)
  • After Access::getAssetRules (id:7531 name:com_content.article.3730) (7.38KB) (50μs)
  • beforeRenderRawModule mod_custom (Search for more information...) (1.34MB) (261ms)
  • afterRenderRawModule mod_custom (Search for more information...) (4.29KB) (190μs)
  • beforeRenderModule mod_custom (Search for more information...) (736B) (3μs)
  • afterRenderModule mod_custom (Search for more information...) (5.45KB) (37.95ms)
  • afterRenderComponent com_content (51.98KB) (256ms)
  • Before Access::getAssetRules (id:8 name:com_content) (49.8KB) (47.47ms)
  • After Access::getAssetRules (id:8 name:com_content) (6.17KB) (38μs)
  • afterDispatch (17.7KB) (12.9ms)
  • beforeRenderRawModule mod_articles_category (READ MORE...) (32.27KB) (425μs)
  • afterRenderRawModule mod_articles_category (READ MORE...) (76.09KB) (1.02s)
  • beforeRenderRawModule mod_custom (BOOST YOUR IMMUNE DEFENSE) (6.45KB) (29μs)
  • afterRenderRawModule mod_custom (BOOST YOUR IMMUNE DEFENSE) (912B) (41μs)
  • beforeRenderRawModule mod_tags_popular (Search) (2.36KB) (14μs)
  • afterRenderRawModule mod_tags_popular (Search) (46.13KB) (1.7s)
  • beforeRenderRawModule mod_custom (Check this before you buy a Q10 product) (944B) (25μs)
  • afterRenderRawModule mod_custom (Check this before you buy a Q10 product) (928B) (42μs)
  • beforeRenderRawModule mod_custom (the Vitamin and Mineral Guide) (736B) (10μs)
  • afterRenderRawModule mod_custom (the Vitamin and Mineral Guide) (992B) (21μs)
  • beforeRenderModule mod_articles_category (READ MORE...) (276.94KB) (3.99ms)
  • afterRenderModule mod_articles_category (READ MORE...) (1.25KB) (57μs)
  • beforeRenderModule mod_custom (BOOST YOUR IMMUNE DEFENSE) (6.81KB) (13μs)
  • afterRenderModule mod_custom (BOOST YOUR IMMUNE DEFENSE) (1.28KB) (1.08ms)
  • beforeRenderModule mod_tags_popular (Search) (1.98KB) (21μs)
  • afterRenderModule mod_tags_popular (Search) (2.52KB) (39μs)
  • beforeRenderModule mod_custom (Check this before you buy a Q10 product) (1.31KB) (11μs)
  • afterRenderModule mod_custom (Check this before you buy a Q10 product) (1.28KB) (21μs)
  • beforeRenderModule mod_custom (the Vitamin and Mineral Guide) (352B) (9μs)
  • afterRenderModule mod_custom (the Vitamin and Mineral Guide) (1.28KB) (18μs)
  • beforeRenderRawModule mod_menu (Main Menu - English) (22.53KB) (411μs)
  • afterRenderRawModule mod_menu (Main Menu - English) (191.29KB) (3.49ms)
  • beforeRenderModule mod_menu (Main Menu - English) (720B) (5μs)
  • afterRenderModule mod_menu (Main Menu - English) (4.86KB) (54μs)
  • beforeRenderRawModule mod_languages (Sprogskift) (3.94KB) (18μs)
  • afterRenderRawModule mod_languages (Sprogskift) (20.87KB) (39.18ms)
  • beforeRenderModule mod_languages (Sprogskift) (720B) (5μs)
  • afterRenderModule mod_languages (Sprogskift) (5.31KB) (21μs)
  • beforeRenderRawModule mod_finder () (6.34KB) (10μs)
  • afterRenderRawModule mod_finder () (128.95KB) (2.95ms)
  • beforeRenderModule mod_finder () (704B) (5μs)
  • afterRenderModule mod_finder () (3.29KB) (32μs)
  • beforeRenderRawModule mod_custom () (6.62KB) (142μs)
  • afterRenderRawModule mod_custom () (21.95KB) (8.7ms)
  • beforeRenderModule mod_custom () (704B) (5μs)
  • afterRenderModule mod_custom () (1.23KB) (44μs)
  • beforeRenderRawModule mod_menu (Main Menu - English) (5.07KB) (93μs)
  • afterRenderRawModule mod_menu (Main Menu - English) (6.52KB) (2.98ms)
  • beforeRenderModule mod_menu (Main Menu - English) (720B) (5μs)
  • afterRenderModule mod_menu (Main Menu - English) (1.25KB) (47μs)
  • beforeRenderRawModule mod_languages (Sprogskift Mobil) (912B) (17μs)
  • afterRenderRawModule mod_languages (Sprogskift Mobil) (3.89KB) (607μs)
  • beforeRenderModule mod_languages (Sprogskift Mobil) (720B) (15μs)
  • afterRenderModule mod_languages (Sprogskift Mobil) (1.27KB) (29μs)
  • beforeRenderRawModule mod_finder () (2.3KB) (8μs)
  • afterRenderRawModule mod_finder () (6.29KB) (12.56ms)
  • beforeRenderModule mod_finder () (704B) (4μs)
  • afterRenderModule mod_finder () (3.73KB) (44μs)
  • beforeRenderRawModule mod_custom () (8.66KB) (169μs)
  • afterRenderRawModule mod_custom () (944B) (126μs)
  • beforeRenderModule mod_custom () (704B) (2μs)
  • afterRenderModule mod_custom () (2.43KB) (22μs)
  • beforeRenderRawModule mod_custom () (688B) (84μs)
  • afterRenderRawModule mod_custom () (896B) (974μs)
  • beforeRenderModule mod_custom () (704B) (4μs)
  • afterRenderModule mod_custom () (2.71KB) (27μs)
  • afterRender (162.77KB) (20.8ms)
  • 1 x afterRenderRawModule mod_tags_popular (Search) (46.13KB) (46.6%)
    1.70s
    1 x afterRenderRawModule mod_articles_category (READ MORE...) (76.09KB) (27.93%)
    1.02s
    1 x beforeRenderRawModule mod_custom (Search for more information...) (1.34MB) (7.16%)
    260.75ms
    1 x afterRenderComponent com_content (51.98KB) (7.03%)
    256.15ms
    1 x After Access::preloadPermissions (com_content) (3.2MB) (2.09%)
    76.33ms
    1 x afterInitialise (1.27MB) (1.94%)
    70.54ms
    1 x Before Access::getAssetRules (id:8 name:com_content) (49.8KB) (1.3%)
    47.47ms
    1 x afterRoute (897.2KB) (1.09%)
    39.88ms
    1 x afterRenderRawModule mod_languages (Sprogskift) (20.87KB) (1.08%)
    39.18ms
    1 x afterRenderModule mod_custom (Search for more information...) (5.45KB) (1.04%)
    37.95ms
    1 x afterRender (162.77KB) (0.57%)
    20.80ms
    1 x afterDispatch (17.7KB) (0.35%)
    12.90ms
    1 x afterRenderRawModule mod_finder () (6.29KB) (0.34%)
    12.56ms
    1 x beforeRenderComponent com_content (23.02KB) (0.33%)
    12.10ms
    1 x afterRenderRawModule mod_custom () (21.95KB) (0.24%)
    8.70ms
    1 x After Access::preloadComponents (all components) (97.34KB) (0.19%)
    6.76ms
    1 x beforeRenderModule mod_articles_category (READ MORE...) (276.94KB) (0.11%)
    3.99ms
    1 x afterLoad (456.41KB) (0.1%)
    3.53ms
    1 x afterRenderRawModule mod_menu (Main Menu - English) (191.29KB) (0.1%)
    3.49ms
    1 x afterRenderRawModule mod_menu (Main Menu - English) (6.52KB) (0.08%)
    2.98ms
    1 x afterRenderRawModule mod_finder () (128.95KB) (0.08%)
    2.95ms
    1 x afterRenderModule mod_custom (BOOST YOUR IMMUNE DEFENSE) (1.28KB) (0.03%)
    1.08ms
    1 x afterRenderRawModule mod_custom () (896B) (0.03%)
    974μs
    1 x afterRenderRawModule mod_languages (Sprogskift Mobil) (3.89KB) (0.02%)
    607μs
    1 x beforeRenderRawModule mod_articles_category (READ MORE...) (32.27KB) (0.01%)
    425μs
    1 x beforeRenderRawModule mod_menu (Main Menu - English) (22.53KB) (0.01%)
    411μs
    1 x Before Access::preloadComponents (all components) (33.23KB) (0.01%)
    244μs
    1 x afterRenderRawModule mod_custom (Search for more information...) (4.29KB) (0.01%)
    190μs
    1 x beforeRenderRawModule mod_custom () (8.66KB) (0%)
    169μs
    1 x beforeRenderRawModule mod_custom () (6.62KB) (0%)
    142μs
    1 x afterRenderRawModule mod_custom () (944B) (0%)
    126μs
    1 x Before Access::getAssetRules (id:7531 name:com_content.article.3730) (130.65KB) (0%)
    121μs
    1 x beforeRenderRawModule mod_menu (Main Menu - English) (5.07KB) (0%)
    93μs
    1 x beforeRenderRawModule mod_custom () (688B) (0%)
    84μs
    1 x afterRenderModule mod_articles_category (READ MORE...) (1.25KB) (0%)
    57μs
    1 x afterRenderModule mod_menu (Main Menu - English) (4.86KB) (0%)
    54μs
    1 x After Access::getAssetRules (id:7531 name:com_content.article.3730) (7.38KB) (0%)
    50μs
    1 x afterRenderModule mod_menu (Main Menu - English) (1.25KB) (0%)
    47μs
    1 x afterRenderModule mod_custom () (1.23KB) (0%)
    44μs
    1 x afterRenderModule mod_finder () (3.73KB) (0%)
    44μs
    1 x afterRenderRawModule mod_custom (Check this before you buy a Q10 product) (928B) (0%)
    42μs
    1 x afterRenderRawModule mod_custom (BOOST YOUR IMMUNE DEFENSE) (912B) (0%)
    41μs
    1 x afterRenderModule mod_tags_popular (Search) (2.52KB) (0%)
    39μs
    1 x After Access::getAssetRules (id:8 name:com_content) (6.17KB) (0%)
    38μs
    1 x afterRenderModule mod_finder () (3.29KB) (0%)
    32μs
    1 x beforeRenderRawModule mod_custom (BOOST YOUR IMMUNE DEFENSE) (6.45KB) (0%)
    29μs
    1 x afterRenderModule mod_languages (Sprogskift Mobil) (1.27KB) (0%)
    29μs
    1 x afterRenderModule mod_custom () (2.71KB) (0%)
    27μs
    1 x beforeRenderRawModule mod_custom (Check this before you buy a Q10 product) (944B) (0%)
    25μs
    1 x afterRenderModule mod_custom () (2.43KB) (0%)
    22μs
    1 x afterRenderRawModule mod_custom (the Vitamin and Mineral Guide) (992B) (0%)
    21μs
    1 x beforeRenderModule mod_tags_popular (Search) (1.98KB) (0%)
    21μs
    1 x afterRenderModule mod_custom (Check this before you buy a Q10 product) (1.28KB) (0%)
    21μs
    1 x afterRenderModule mod_languages (Sprogskift) (5.31KB) (0%)
    21μs
    1 x afterRenderModule mod_custom (the Vitamin and Mineral Guide) (1.28KB) (0%)
    18μs
    1 x beforeRenderRawModule mod_languages (Sprogskift) (3.94KB) (0%)
    18μs
    1 x Before Access::preloadPermissions (com_content) (1.6KB) (0%)
    17μs
    1 x beforeRenderRawModule mod_languages (Sprogskift Mobil) (912B) (0%)
    17μs
    1 x beforeRenderModule mod_languages (Sprogskift Mobil) (720B) (0%)
    15μs
    1 x beforeRenderRawModule mod_tags_popular (Search) (2.36KB) (0%)
    14μs
    1 x beforeRenderModule mod_custom (BOOST YOUR IMMUNE DEFENSE) (6.81KB) (0%)
    13μs
    3 x beforeRenderModule mod_custom () (704B) (0%)
    11μs
    1 x beforeRenderModule mod_custom (Check this before you buy a Q10 product) (1.31KB) (0%)
    11μs
    1 x beforeRenderRawModule mod_custom (the Vitamin and Mineral Guide) (736B) (0%)
    10μs
    2 x beforeRenderModule mod_menu (Main Menu - English) (720B) (0%)
    10μs
    1 x beforeRenderRawModule mod_finder () (6.34KB) (0%)
    10μs
    1 x beforeRenderModule mod_custom (the Vitamin and Mineral Guide) (352B) (0%)
    9μs
    2 x beforeRenderModule mod_finder () (704B) (0%)
    9μs
    1 x beforeRenderRawModule mod_finder () (2.3KB) (0%)
    8μs
    1 x beforeRenderModule mod_languages (Sprogskift) (720B) (0%)
    5μs
    1 x beforeRenderModule mod_custom (Search for more information...) (736B) (0%)
    3μs
44 statements were executed, 9 of which were duplicates, 35 unique3.03s1.15MB
  • SELECT @@SESSION.sql_mode;420μs968B/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:334Copy
  • SELECT `data` FROM `has_session` WHERE `session_id` = ?314μs1008BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:261Copy
  • SELECT `session_id` FROM `has_session` WHERE `session_id` = :session_id LIMIT 165μs1.3KBParams/libraries/src/Session/MetadataManager.php:187Copy
  • INSERT INTO `has_session` (`session_id`,`guest`,`time`,`userid`,`username`,`client_id`) VALUES (:session_id, :guest, :time, :user_id, :username, :client_id)2.54ms944BParams/libraries/src/Session/MetadataManager.php:260Copy
  • SELECT `extension_id` AS `id`,`element` AS `option`,`params`,`enabled` FROM `has_extensions` WHERE `type` = 'component' AND `state` = 0 AND `enabled` = 11.31ms1.61KB/libraries/src/Component/ComponentHelper.php:399Copy
  • SELECT `id`,`rules` FROM `has_viewlevels`263μs656B/libraries/src/Access/Access.php:955Copy
  • SELECT `b`.`id` FROM `has_usergroups` AS `a` LEFT JOIN `has_usergroups` AS `b` ON `b`.`lft` <= `a`.`lft` AND `b`.`rgt` >= `a`.`rgt` WHERE `a`.`id` = :guest127μs1.33KBParams/libraries/src/Access/Access.php:868Copy
  • SELECT `folder` AS `type`,`element` AS `name`,`params` AS `params`,`extension_id` AS `id` FROM `has_extensions` WHERE `enabled` = 1 AND `type` = 'plugin' AND `state` IN (0,1) AND `access` IN (:preparedArray1,:preparedArray2) ORDER BY `ordering`4.94ms3.98KBParams/libraries/src/Plugin/PluginHelper.php:294Copy
  • SELECT * FROM `has_languages` WHERE `published` = 1 ORDER BY `ordering` ASC130μs2.33KB/libraries/src/Language/LanguageHelper.php:142Copy
  • SELECT `element`,`name`,`client_id`,`extension_id` FROM `has_extensions` WHERE `type` = 'language' AND `state` = 0 AND `enabled` = 1119μs1008B/libraries/src/Language/LanguageHelper.php:213Copy
  • SELECT * FROM has_rsform_config162μs1.06KB/administrator/components/com_rsform/helpers/config.php:52Copy
  • SELECT `m`.`id`,`m`.`menutype`,`m`.`title`,`m`.`alias`,`m`.`note`,`m`.`link`,`m`.`type`,`m`.`level`,`m`.`language`,`m`.`browserNav`,`m`.`access`,`m`.`params`,`m`.`home`,`m`.`img`,`m`.`template_style_id`,`m`.`component_id`,`m`.`parent_id`,`m`.`path` AS `route`,`e`.`element` AS `component` FROM `has_menu` AS `m` LEFT JOIN `has_extensions` AS `e` ON `m`.`component_id` = `e`.`extension_id` WHERE ( (`m`.`published` = 1 AND `m`.`parent_id` > 0 AND `m`.`client_id` = 0) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :currentDate1)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :currentDate2) ORDER BY `m`.`lft`3.58ms165.8KBParams/libraries/src/Menu/SiteMenu.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray1,:preparedArray2)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`247μs3.92KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `id`,`home`,`template`,`s`.`params`,`inheritable`,`parent` FROM `has_template_styles` AS `s` LEFT JOIN `has_extensions` AS `e` ON `e`.`element` = `s`.`template` AND `e`.`type` = 'template' AND `e`.`client_id` = `s`.`client_id` WHERE `s`.`client_id` = 0 AND `e`.`enabled` = 14.53ms848B/administrator/components/com_templates/src/Model/StyleModel.php:773Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `has_assets` WHERE `name` IN (:preparedArray1,:preparedArray2,:preparedArray3,:preparedArray4,:preparedArray5,:preparedArray6,:preparedArray7,:preparedArray8,:preparedArray9,:preparedArray10,:preparedArray11,:preparedArray12,:preparedArray13,:preparedArray14,:preparedArray15,:preparedArray16,:preparedArray17,:preparedArray18,:preparedArray19,:preparedArray20,:preparedArray21,:preparedArray22,:preparedArray23,:preparedArray24,:preparedArray25,:preparedArray26,:preparedArray27,:preparedArray28,:preparedArray29,:preparedArray30,:preparedArray31,:preparedArray32,:preparedArray33,:preparedArray34,:preparedArray35,:preparedArray36,:preparedArray37,:preparedArray38,:preparedArray39,:preparedArray40)2.18ms7.44KBParams/libraries/src/Access/Access.php:357Copy
  • SELECT `id`,`name`,`rules`,`parent_id` FROM `has_assets` WHERE `name` LIKE :asset OR `name` = :extension OR `parent_id` = 016.97ms397.48KBParams/libraries/src/Access/Access.php:301Copy
  • SHOW FULL COLUMNS FROM `has_content`7.85ms3.02KB/libraries/vendor/joomla/database/src/Mysqli/MysqliDriver.php:625Copy
  • UPDATE `has_content` SET `hits` = (`hits` + 1) WHERE `id` = '3730'9.68ms48B/libraries/src/Table/Table.php:1325Copy
  • SELECT `a`.`id`,`a`.`asset_id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`state`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`version`,`a`.`ordering`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`metadata`,`a`.`featured`,`a`.`language`,`fp`.`featured_up`,`fp`.`featured_down`,`c`.`title` AS `category_title`,`c`.`alias` AS `category_alias`,`c`.`access` AS `category_access`,`c`.`language` AS `category_language`,`fp`.`ordering`,`u`.`name` AS `author`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1) AS `rating`,`v`.`rating_count` AS `rating_count` FROM `has_content` AS `a` INNER JOIN `has_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `has_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `has_users` AS `u` ON `u`.`id` = `a`.`created_by` LEFT JOIN `has_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `has_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE ( (`a`.`id` = :pk AND `c`.`published` > 0 AND `a`.`language` IN (:preparedArray1,:preparedArray2)) AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp)) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`state` IN (:preparedArray3,:preparedArray4)6.44ms22.19KBParams/components/com_content/src/Model/ArticleModel.php:215Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`301μs3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT `m`.`tag_id`,`t`.* FROM `has_contentitem_tag_map` AS `m` INNER JOIN `has_tags` AS `t` ON `m`.`tag_id` = `t`.`id` WHERE `m`.`type_alias` = :contentType AND `m`.`content_item_id` = :id AND `t`.`published` = 1 AND `t`.`access` IN (:preparedArray1,:preparedArray2) AND `language` IN (:preparedArray3,:preparedArray4)11.77ms4.06KBParams/libraries/src/Helper/TagsHelper.php:388Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`2.25ms3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM has_fields AS a LEFT JOIN `has_languages` AS l ON l.lang_code = a.language LEFT JOIN has_users AS uc ON uc.id=a.checked_out LEFT JOIN has_viewlevels AS ag ON ag.id = a.access LEFT JOIN has_users AS ua ON ua.id = a.created_user_id LEFT JOIN has_fields_groups AS g ON g.id = a.group_id LEFT JOIN `has_fields_categories` AS fc ON fc.field_id = a.id WHERE ( (`a`.`context` = :context AND (`fc`.`category_id` IS NULL OR `fc`.`category_id` IN (:preparedArray1,:preparedArray2,:preparedArray3)) AND `a`.`access` IN (:preparedArray4,:preparedArray5)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray6,:preparedArray7)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform AND `a`.`language` IN (:preparedArray8,:preparedArray9) ORDER BY a.ordering ASC823μs4.81KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id4.44ms1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id95μs1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `m`.`id`,`m`.`title`,`m`.`module`,`m`.`position`,`m`.`content`,`m`.`showtitle`,`m`.`params`,`mm`.`menuid` FROM `has_modules` AS `m` LEFT JOIN `has_modules_menu` AS `mm` ON `mm`.`moduleid` = `m`.`id` LEFT JOIN `has_extensions` AS `e` ON `e`.`element` = `m`.`module` AND `e`.`client_id` = `m`.`client_id` WHERE ( ( (`m`.`published` = 1 AND `e`.`enabled` = 1 AND `m`.`client_id` = :clientId AND `m`.`access` IN (:preparedArray1,:preparedArray2)) AND (`m`.`publish_up` IS NULL OR `m`.`publish_up` <= :publishUp)) AND (`m`.`publish_down` IS NULL OR `m`.`publish_down` >= :publishDown)) AND (`mm`.`menuid` = :itemId OR `mm`.`menuid` <= 0) AND `m`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY `m`.`position`,`m`.`ordering`9.07ms180.84KBParams/libraries/src/Cache/Controller/CallbackController.php:51Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`catid`,`a`.`language`, CASE WHEN CHAR_LENGTH(`a`.`alias`) != 0 THEN CONCAT_WS(':', `a`.`id`, `a`.`alias`) ELSE a.id END AS `slug`, CASE WHEN CHAR_LENGTH(`cc`.`alias`) != 0 THEN CONCAT_WS(':', `cc`.`id`, `cc`.`alias`) ELSE cc.id END AS `catslug` FROM `has_content` AS `a` LEFT JOIN `has_categories` AS `cc` ON `cc`.`id` = `a`.`catid` WHERE `a`.`catid` = :catid AND `a`.`state` = :state AND `a`.`access` IN (:preparedArray1,:preparedArray2) AND (`publish_up` IS NULL OR `publish_up` <= :nowDate1) AND (`publish_down` IS NULL OR `publish_down` >= :nowDate2) AND `a`.`language` IN (:preparedArray3,:preparedArray4) ORDER BY CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END DESC187ms161.75KBParams/plugins/content/pagenavigation/src/Extension/PageNavigation.php:188Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`1.39ms3.98KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT custom_data FROM has_extensions WHERE element = 'yootheme' AND folder = 'system' LIMIT 117.16ms536B/templates/yootheme/packages/platform-joomla/src/Storage.php:30Copy
  • SELECT `language`,`id` FROM `has_menu` WHERE `home` = '1' AND `published` = 1 AND `client_id` = 07.88ms704B/libraries/src/Language/Multilanguage.php:123Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id7.8ms1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `alias` FROM `has_content` WHERE `id` = :id3.53ms1.31KBParams/components/com_content/src/Service/Router.php:168Copy
  • SELECT `c2`.`language`,CONCAT_WS(':', `c2`.`id`, `c2`.`alias`) AS `id`,CONCAT_WS(':', `ca`.`id`, `ca`.`alias`) AS `catid` FROM `has_content` AS `c` INNER JOIN `has_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `has_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `has_content` AS `c2` ON `a2`.`id` = `c2`.`id` INNER JOIN `has_categories` AS `ca` ON `c2`.`catid` = `ca`.`id` AND `ca`.`extension` = :extension2 WHERE `c`.`id` = :id AND c2.access IN (1,5) AND c2.language != 'en-GB' AND (c2.publish_up IS NULL OR c2.publish_up <= '2025-02-22 18:04:08') AND (c2.publish_down IS NULL OR c2.publish_down >= '2025-02-22 18:04:08') AND c2.state = 111.23ms3.97KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT `a`.`id`,`a`.`title`,`a`.`alias`,`a`.`introtext`,`a`.`fulltext`,`a`.`checked_out`,`a`.`checked_out_time`,`a`.`catid`,`a`.`created`,`a`.`created_by`,`a`.`created_by_alias`,`a`.`modified`,`a`.`modified_by`,CASE WHEN `a`.`publish_up` IS NULL THEN `a`.`created` ELSE `a`.`publish_up` END AS `publish_up`,`a`.`publish_down`,`a`.`images`,`a`.`urls`,`a`.`attribs`,`a`.`metadata`,`a`.`metakey`,`a`.`metadesc`,`a`.`access`,`a`.`hits`,`a`.`featured`,`a`.`language`,LENGTH(`a`.`fulltext`) AS `readmore`,`a`.`ordering`,`fp`.`featured_up`,`fp`.`featured_down`,CASE WHEN `c`.`published` = 2 AND `a`.`state` > 0 THEN 2 WHEN `c`.`published` != 1 THEN 0 ELSE `a`.`state` END AS `state`,`c`.`title` AS `category_title`,`c`.`path` AS `category_route`,`c`.`access` AS `category_access`,`c`.`alias` AS `category_alias`,`c`.`language` AS `category_language`,`c`.`published`,`c`.`published` AS `parents_published`,`c`.`lft`,CASE WHEN `a`.`created_by_alias` > ' ' THEN `a`.`created_by_alias` ELSE `ua`.`name` END AS `author`,`ua`.`email` AS `author_email`,`uam`.`name` AS `modified_by_name`,`parent`.`title` AS `parent_title`,`parent`.`id` AS `parent_id`,`parent`.`path` AS `parent_route`,`parent`.`alias` AS `parent_alias`,`parent`.`language` AS `parent_language`,COALESCE(NULLIF(ROUND(`v`.`rating_sum` / `v`.`rating_count`, 1), 0), 0) AS `rating`,COALESCE(NULLIF(`v`.`rating_count`, 0), 0) AS `rating_count` FROM `has_content` AS `a` LEFT JOIN `has_categories` AS `c` ON `c`.`id` = `a`.`catid` LEFT JOIN `has_users` AS `ua` ON `ua`.`id` = `a`.`created_by` LEFT JOIN `has_users` AS `uam` ON `uam`.`id` = `a`.`modified_by` LEFT JOIN `has_categories` AS `parent` ON `parent`.`id` = `c`.`parent_id` LEFT JOIN `has_content_frontpage` AS `fp` ON `fp`.`content_id` = `a`.`id` LEFT JOIN `has_content_rating` AS `v` ON `a`.`id` = `v`.`content_id` WHERE `a`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`access` IN (:preparedArray3,:preparedArray4) AND `c`.`published` = 1 AND `a`.`state` = :condition AND (`a`.`publish_up` IS NULL OR `a`.`publish_up` <= :publishUp) AND (`a`.`publish_down` IS NULL OR `a`.`publish_down` >= :publishDown) AND `a`.`language` IN (:preparedArray5,:preparedArray6) ORDER BY RAND() ASC LIMIT 10960ms167.16KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `c`.`id`,`c`.`asset_id`,`c`.`access`,`c`.`alias`,`c`.`checked_out`,`c`.`checked_out_time`,`c`.`created_time`,`c`.`created_user_id`,`c`.`description`,`c`.`extension`,`c`.`hits`,`c`.`language`,`c`.`level`,`c`.`lft`,`c`.`metadata`,`c`.`metadesc`,`c`.`metakey`,`c`.`modified_time`,`c`.`note`,`c`.`params`,`c`.`parent_id`,`c`.`path`,`c`.`published`,`c`.`rgt`,`c`.`title`,`c`.`modified_user_id`,`c`.`version`, CASE WHEN CHAR_LENGTH(`c`.`alias`) != 0 THEN CONCAT_WS(':', `c`.`id`, `c`.`alias`) ELSE `c`.`id` END as `slug` FROM `has_categories` AS `s` INNER JOIN `has_categories` AS `c` ON (`s`.`lft` < `c`.`lft` AND `c`.`lft` < `s`.`rgt` AND `c`.`language` IN (:preparedArray3,:preparedArray4)) OR (`c`.`lft` <= `s`.`lft` AND `s`.`rgt` <= `c`.`rgt`) WHERE (`c`.`extension` = :extension OR `c`.`extension` = 'system') AND `c`.`access` IN (:preparedArray1,:preparedArray2) AND `c`.`published` = 1 AND `s`.`id` = :id ORDER BY `c`.`lft`6.06ms4KBParams/libraries/src/Categories/Categories.php:375Copy
  • SELECT MAX(`tag_id`) AS `tag_id`,COUNT(*) AS `count`,MAX(`t`.`title`) AS `title`,MAX(`t`.`access`) AS `access`,MAX(`t`.`alias`) AS `alias`,MAX(`t`.`params`) AS `params`,MAX(`t`.`language`) AS `language` FROM `has_contentitem_tag_map` AS `m` INNER JOIN `has_ucm_content` AS `ucm` ON `m`.`content_item_id` = `ucm`.`core_content_item_id` AND `m`.`type_id` = `ucm`.`core_type_id` INNER JOIN `has_categories` AS `cat` ON `ucm`.`core_catid` = `cat`.`id` INNER JOIN `has_tags` AS `t` ON `tag_id` = `t`.`id` INNER JOIN `has_ucm_content` AS `c` ON `m`.`core_content_id` = `c`.`core_content_id` WHERE `t`.`access` IN (:preparedArray1,:preparedArray2) AND `t`.`published` = 1 AND `cat`.`published` > 0 AND `t`.`language` IN (:preparedArray3,:preparedArray4) AND `m`.`type_alias` = `c`.`core_type_alias` AND `c`.`core_state` = 1 AND (`c`.`core_access` IN (:preparedArray5,:preparedArray6) OR `c`.`core_access` = 0) AND (`c`.`core_publish_up` IS NULL OR `c`.`core_publish_up` = :nullDate2 OR `c`.`core_publish_up` <= :nowDate2) AND (`c`.`core_publish_down` IS NULL OR `c`.`core_publish_down` = :nullDate3 OR `c`.`core_publish_down` >= :nowDate3) GROUP BY `tag_id`,`t`.`title`,`t`.`access`,`t`.`alias` ORDER BY RAND() LIMIT 151.69s2.75KBParams/modules/mod_tags_popular/src/Helper/TagsPopularHelper.php:183Copy
  • SELECT `c2`.`language`,`c2`.`id` FROM `has_menu` AS `c` INNER JOIN `has_associations` AS `a` ON `a`.`id` = `c`.`id` AND `a`.`context` = :context INNER JOIN `has_associations` AS `a2` ON `a`.`key` = `a2`.`key` INNER JOIN `has_menu` AS `c2` ON `a2`.`id` = `c2`.`id` WHERE `c`.`id` = :id24.8ms1.44KBParams/libraries/src/Language/Associations.php:145Copy
  • SELECT `name`,`element` FROM `has_extensions` WHERE `type` = 'plugin' AND `folder` = 'finder' AND `enabled` = 1210μs640B/administrator/components/com_finder/src/Helper/LanguageHelper.php:135Copy
  • SELECT `title` FROM `has_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1,5)118μs584B/administrator/components/com_finder/src/Indexer/Taxonomy.php:314Copy
  • SELECT DISTINCT a.id, a.title, a.name, a.checked_out, a.checked_out_time, a.note, a.state, a.access, a.created_time, a.created_user_id, a.ordering, a.language, a.fieldparams, a.params, a.type, a.default_value, a.context, a.group_id, a.label, a.description, a.required, a.only_use_in_subform,l.title AS language_title, l.image AS language_image,uc.name AS editor,ag.title AS access_level,ua.name AS author_name,g.title AS group_title, g.access as group_access, g.state AS group_state, g.note as group_note FROM has_fields AS a LEFT JOIN `has_languages` AS l ON l.lang_code = a.language LEFT JOIN has_users AS uc ON uc.id=a.checked_out LEFT JOIN has_viewlevels AS ag ON ag.id = a.access LEFT JOIN has_users AS ua ON ua.id = a.created_user_id LEFT JOIN has_fields_groups AS g ON g.id = a.group_id WHERE ( (`a`.`context` = :context AND `a`.`access` IN (:preparedArray1,:preparedArray2)) AND (`a`.`group_id` = 0 OR `g`.`access` IN (:preparedArray3,:preparedArray4)) AND `a`.`state` = :state) AND (`a`.`group_id` = 0 OR `g`.`state` = :gstate) AND `a`.`only_use_in_subform` = :only_use_in_subform AND `a`.`language` IN (:preparedArray5,:preparedArray6) ORDER BY a.ordering ASC5.02ms4.75KBParams/libraries/src/MVC/Model/BaseDatabaseModel.php:166Copy
  • SELECT `title` FROM `has_finder_taxonomy` WHERE `parent_id` = 1 AND `state` = 1 AND `access` IN (1,5)151μs584B/administrator/components/com_finder/src/Indexer/Taxonomy.php:314Copy
  • SELECT SUM(CASE WHEN `a`.`next_execution` <= :now THEN 1 ELSE 0 END) AS due_count,SUM(CASE WHEN `a`.`locked` IS NULL THEN 0 ELSE 1 END) AS locked_count FROM `has_scheduler_tasks` AS `a` WHERE `a`.`state` = 18.8ms1.37KBParams/administrator/components/com_scheduler/src/Model/TasksModel.php:466Copy
  • SELECT `session_id` FROM `has_session` WHERE `session_id` = ?117μs1KBParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:291Copy
  • UPDATE `has_session` SET `data` = ? , `time` = ? WHERE `session_id` = ?9ms592BParams/libraries/vendor/joomla/session/src/Handler/DatabaseHandler.php:318Copy