Kolesterolsænkende medicin kan skade muskelvævet

Kolesterolsænkende medicin kan skade muskelvævetSelv kortvarig anvendelse af de hyppigt anvendte kolesterolsænkende lægemidler – også kaldet for statiner – kan forårsage potentielt farlige bivirkninger, advarer forskere.


De hyppigt anvendte kolesterolsænkende lægemidler, der går under fællesbetegnelsen statiner, har længe været mistænkt for at svække udholdenheden og forårsage skader på muskelvævet. Nu er et hold forskere fra Columbia University – College of Physicians & Surgeons nået et skridt nærmere en forklaring på fænomenet. Ved at undersøge 34 personer, som alle fik medicinsk behandling (atorvastatin) mod forhøjet kolesterol, observerede forskerne, at statin-behandlingen foruden at reducere mængden af kolesterol førte til en voldsom reduktion af kroppens coenzym Q10-niveauer. Coenzym Q10 er et vitamin-beslægtet stof, som celler behøver for at kunne producere energi.

Hæmmer vigtig energi-katalysator

Hos de 34 testpersoner var blodets indhold af coenzym Q10 halveret efter 30 dage. Allerede efter de første to uger kunne forskerne observere en signifikant sænkning af Q10-indholdet, hvilket er ensbetydende med, at selv kortvarig anvendelse af statin-præparater har negativ indvirkning på kroppens Q10-status og dermed hæmmer denne vigtige energi-katalysator. Ligesom kolesterol, bliver coenzym Q10 dannet i leveren, og da begge stoffer udgår fra samme biokemiske grundsubstans, vil en hæmning af kolesterol-syntesen automatisk hæmme produktionen af coenzym Q10.

Muskelsvækkelse

Forskergruppen konkluderer på baggrund af deres undersøgelse, at en omfattende reduktion af kroppens coenzym Q10-produktion kan forklare de bivirkninger, som ofte ses i forbindelse med brug af statin-præparater, nemlig svækket udholdenhed, muskelsmerter og myoglobinuria (et tegn på nedbrydning af muskelvæv) Forskerne bag undersøgelsen tilskynder til, at patienter i statin-behandling tager et tilskud af coenzym Q10 for at kompensere for det tab, som den medicinske behandling er årsag til.

Kilde:
Archives of Neurology, 2004;61:889-892

 

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