Cholesterinsenker - die potenzielle Gefahr für Ihr Muskelgewebe

Cholesterinsenker - die potenzielle Gefahr für Ihr MuskelgewebeSelbst eine kurzfristige Einnahme von cholesterinsenkenden Medikamenten kann möglicherweise schädliche Nebenwirkungen wie Belastungsintoleranz und Muskelschmerzen nach sich ziehen, berichten Wissenschaftler.

Statine sind eine weit verbreitete Art von Cholesterinsenkern, die vermutlich zu Belastungsintoleranz und Muskelschäden führen. Jetzt ist ein Forscherteam des College of Physicians & Surgeons an der Universität Columbia der Antwort auf die Frage nach dem Warum einen Schritt näher gekommen. In der Juni-Ausgabe 2004 der Zeitschrift Archives of Neurology beschreiben die Wissenschaftler bei 34 Patienten, die Cholesterinsenker (Atorvastatin) einnahmen, einen massiven Rückgang der Coenzym Q10-Werte. Diese vitaminartige Substanz wird in den menschlichen Körperzellen für die Energieproduktion benötigt.

Wichtiger Energieumwandler blockiert

Die Q10-Werte im Blut wurden zu Beginn, nach 14 Tagen und nach einem Monat gemessen, um die Entwicklung zu beobachten. Nach 14-tägiger Statineinnahme stellte sich heraus, dass das Coenzym Q10 erheblich reduziert war. Nach einem Monat zeigte sich ein alarmierender Rückgang von 50 Prozent. Aufgrund dieser Erkenntnisse folgerten die Wissenschaftler, dass sich selbst eine kurzfristige Einnahme von Statinen negativ auf den wichtigen Energieumwandler Q10 auswirkt.
Die beiden natürlichen Substanzen Coenzym Q10 und Cholesterin teilen sich denselben biochemischen Syntheseweg in der Leber. Wird der Aufbau von Cholesterin jedoch blockiert, so kann auch kein Coenzym Q10 produziert werden.

Muskuläre Beeinträchtigung

Belastungsintoleranz, Muskelschmerzen und Myoglobinurie (ein Anzeichen für Muskelschwund) sind häufig auftretende Nebenwirkungen von Cholesterinsenkern. Das Forscherteam schloss aus der Studie, dass diese auf die drastische Reduktion des Coenzyms Q10, die bei der Einnahme von Statinen beobachtet wurde, zurückgeführt werden könnten.

Als Maßnahme gegen den durch die Statine verursachten Q10-Rückgang empfehlen die Wissenschaftler den Patienten, ihre Nahrung neben dem cholesterinsenkenden Medikament mit Coenzym Q10 zu ergänzen.

Quelle:

Archives of Neurology, 2004;61:889-892

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